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高危老年患者二尖瓣手术后的死亡率结果和预测因素:海德堡经验。

Outcomes and Predictors of Mortality After Mitral Valve Surgery in High-Risk Elderly Patients: The Heidelberg Experience.

机构信息

Department of Cardiac Surgery, Heart and Marfan Center, University of Heidelberg, Heidelberg, Germany.

Department of Cardiac Surgery, University Hospital Oldenburg, European Medical School Oldenburg-Groningen, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

出版信息

Med Sci Monit. 2017 Dec 31;23:6193-6200. doi: 10.12659/msm.906003.

Abstract

BACKGROUND Overall, life expectancy at the age of 80 has significantly increased in the industrialized world and the proportion of this age class undergoing cardiac surgery has also grown. In this context, we have analyzed a contemporary series of octogenarians undergoing mitral valve surgery at our institution. MATERIAL AND METHODS We performed a retrospective analysis of 138 consecutive octogenarians receiving mitral valve surgery between January 2006 and April 2017. Preoperative comorbidities, early mortality, postoperative clinical course, and predictors of mortality were examined. RESULTS The mean age was 82.4±2.0 years and 50% (n=69) were male. Preoperative comorbidities included history of heart infarction (24.6%, n=34), chronic renal failure (37.7%, n=52), and COPD (27.5%, n=38). A total of 52.9% (n=73) had a history of previous cardiac decompensation, while 20 (14.5%) presented with cardiogenic shock or cardiac arrest. In all, 33 patients (23.9%) underwent emergency surgery. There were only 39 isolated mitral valve procedures, while 99 patients (71.7%) underwent various concomitant procedures. The intensive care unit average length of stay was 5.3±7.5 days. Respiratory complications and sepsis were the most frequent postoperative complications. Emergency surgery and concomitant coronary artery bypass grafting were the most important predictors of early mortality. The overall 30-day mortality was 18.1% (n=25). The mean follow-up time was 1.7±2.3 years. CONCLUSIONS Octogenarians are increasingly represented in cardiac surgery and combined procedures. Prudent patient selection is necessary for optimizing postoperative outcomes among the elderly. In our seriously ill octogenarian cohort, mitral valve surgery was associated with moderate but acceptable mid-term survival.

摘要

背景

在工业化世界,80 岁时的预期寿命显著提高,接受心脏手术的 80 岁以上年龄段的比例也有所增加。在此背景下,我们分析了本机构连续 138 例 80 岁以上接受二尖瓣手术的患者。

材料和方法

我们对 2006 年 1 月至 2017 年 4 月期间连续 138 例 80 岁以上接受二尖瓣手术的患者进行了回顾性分析。检查了术前合并症、早期死亡率、术后临床过程和死亡率的预测因素。

结果

平均年龄为 82.4±2.0 岁,50%(n=69)为男性。术前合并症包括心肌梗死史(24.6%,n=34)、慢性肾功能衰竭(37.7%,n=52)和 COPD(27.5%,n=38)。共有 52.9%(n=73)有既往心脏失代偿的病史,20 例(14.5%)表现为心源性休克或心脏骤停。共有 33 例(23.9%)患者接受急诊手术。仅行单纯二尖瓣手术 39 例,行各种同时进行的手术 99 例(71.7%)。重症监护病房平均住院时间为 5.3±7.5 天。呼吸并发症和败血症是最常见的术后并发症。急诊手术和同时进行的冠状动脉旁路移植术是早期死亡率的最重要预测因素。总的 30 天死亡率为 18.1%(n=25)。平均随访时间为 1.7±2.3 年。

结论

80 岁以上人群在心脏手术和联合手术中的比例逐渐增加。对老年人进行手术时需要谨慎选择患者,以优化术后效果。在我们病情严重的 80 岁以上患者队列中,二尖瓣手术与中等但可接受的中期生存相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdff/5757865/fcd917eeef02/medscimonit-23-6193-g001.jpg

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