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唾液腺内镜在治疗无涎石病的成人慢性复发性腮腺炎中的应用

Sialendoscopy in treatment of adult chronic recurrent parotitis without sialolithiasis.

作者信息

Jokela Johanna, Haapaniemi Aaro, Mäkitie Antti, Saarinen Riitta

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, P.O. Box 263, 00029 HUS, Helsinki, Finland.

Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden.

出版信息

Eur Arch Otorhinolaryngol. 2018 Mar;275(3):775-781. doi: 10.1007/s00405-017-4854-7. Epub 2017 Dec 30.

Abstract

OBJECTIVE

The aim of this prospective study was to evaluate the efficacy of sialendoscopy in the management of adult chronic recurrent parotitis without sialolithiasis. In addition, preliminary results of an initial randomized placebo-controlled trial of single-dose intraductal steroid injection given concurrently with sialendoscopy, are presented.

METHODS

Forty-nine adult patients with chronic recurrent parotitis without sialoliths were included in this study. They underwent sialendoscopy and were randomized to receive either a concurrent intraductal injection of isotonic saline solution or 125 mg of hydrocortisone. Symptom severity was evaluated with visual analogue scale (VAS) and by recording symptom frequency and course with a multiple-choice questionnaire completed preoperatively and at 3, 6, and 12 months after the procedure.

RESULTS

The mean VAS score was 5.6 preoperatively and dropped to 2.9 at 3 months, 3.0 at 6 months, and 2.7 at 12 months after the procedure. The VAS score and the frequency of symptoms were significantly lower at 3 (p < 0.001), 6 (p < 0.001) and 12 (p < 0.001) months after the procedure when compared with the preoperative scores indicating that sialendoscopy reduces the symptoms of recurrent parotitis. However, complete permanent resolution of symptoms was rare. Single-dose steroid injection concomitant to sialendoscopy provided no additional benefit, but the current study is not sufficiently powered to determine a clinical difference between the steroid and non-steroid groups.

CONLUSION

Sialendoscopy appears to reduce the symptoms of chronic recurrent parotitis. While total permanent symptom remission is rare, sialendoscopy can be considered a safe and relatively efficacious treatment method for this patient group.

摘要

目的

本前瞻性研究旨在评估唾液腺内镜在治疗无涎石病的成人慢性复发性腮腺炎中的疗效。此外,还介绍了一项初步随机安慰剂对照试验的结果,该试验将唾液腺内镜检查与单剂量导管内注射类固醇同时进行。

方法

本研究纳入了49例无涎石的成人慢性复发性腮腺炎患者。他们接受了唾液腺内镜检查,并随机接受导管内注射等渗盐溶液或125毫克氢化可的松。通过视觉模拟量表(VAS)评估症状严重程度,并在术前以及术后3个月、6个月和12个月通过完成一份多项选择题问卷记录症状频率和病程。

结果

术前平均VAS评分为5.6,术后3个月降至2.9,6个月降至3.0,12个月降至2.7。与术前评分相比,术后3个月(p < 0.001)、6个月(p < 0.001)和12个月(p < 0.001)时VAS评分和症状频率显著降低,表明唾液腺内镜可减轻复发性腮腺炎的症状。然而,症状完全永久性缓解的情况很少见。唾液腺内镜检查同时进行单剂量类固醇注射未带来额外益处,但目前的研究样本量不足以确定类固醇组和非类固醇组之间的临床差异。

结论

唾液腺内镜似乎可减轻慢性复发性腮腺炎的症状。虽然完全永久性症状缓解很少见,但唾液腺内镜可被认为是该患者群体一种安全且相对有效的治疗方法。

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