Hai-Long Wang, Xiao-Hua Pang, Jian-Jun Yang
Department of Cardiology, Chongqing Three Gorges Central Hospital, Chongqing, China.
J Coll Physicians Surg Pak. 2018 Jan;28(1):56-60. doi: 10.29271/jcpsp.2018.01.56.
The effect of heart-type fatty acid binding protein (H-FABP) remains unclear on the quality of the prognoses of patients with acute coronary syndrome (ACS). The authors searched the EMBASE, PubMed, Cochrane Library, and Medline electronic databases from their respective inceptions throughout June 2017. Odds ratios were pooled from individual studies, and conducted heterogeneity analysis, quality assessment, and publication bias analysis. A total of four studies with 1,994 patients were included (554 positive patients; 1,440 negative patients). Pooled analysis of these studies showed that patients positive for H-FABP had higher incidence for mortality (OR, 6.39; p<0.01) and cardiac events (OR, 3.94; P<0.01) than negative patients, but myocardial infarction (MI) (OR, 1.43; P=0.32) showed no significant differences. ACS patients positive for H-FABP had higher rates in cardiac events and mortality. The incidence of MI showed no significant difference, possibly because this study was based on limited data from randomized studies. Additional substantial randomized controlled trials certainly needed to verify these discovery.
心脏型脂肪酸结合蛋白（H-FABP）对急性冠状动脉综合征（ACS）患者预后质量的影响仍不明确。作者检索了EMBASE、PubMed、Cochrane图书馆和Medline电子数据库，检索时间从各数据库建库起至2017年6月。从各项研究中汇总比值比，并进行异质性分析、质量评估和发表偏倚分析。共纳入4项研究，涉及1994例患者（554例阳性患者；1440例阴性患者）。对这些研究的汇总分析表明，H-FABP阳性患者的死亡率（比值比，6.39；p<0.01）和心脏事件发生率（比值比，3.94；P<0.01）高于阴性患者，但心肌梗死（MI）（比值比，1.43；P=0.32）无显著差异。H-FABP阳性的ACS患者心脏事件发生率和死亡率较高。MI的发生率无显著差异，可能是因为本研究基于随机研究的有限数据。当然需要更多大规模的随机对照试验来验证这些发现。
