Polycystins and mechanotransduction in bone.
作者信息
Gargalionis Antonios N, Basdra Efthimia K, Papavassiliou Athanasios G
机构信息
Athanasios G. Papavassiliou: Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
出版信息
Oncotarget. 2017 Nov 13;8(63):106159-106160. doi: 10.18632/oncotarget.22421. eCollection 2017 Dec 5.
Abstract
摘要
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Mechanosensor polycystin-1 potentiates differentiation of human osteoblastic cells by upregulating Runx2 expression via induction of JAK2/STAT3 signaling axis.机械传感器多囊蛋白-1通过诱导JAK2/STAT3信号轴上调Runx2表达，增强人成骨细胞的分化。
Cell Mol Life Sci. 2017 Mar;74(5):921-936. doi: 10.1007/s00018-016-2394-8. Epub 2016 Oct 3.
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Physiological mechanisms and therapeutic potential of bone mechanosensing.骨力感受的生理机制及治疗潜力
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PLoS One. 2014 Dec 2;9(12):e114198. doi: 10.1371/journal.pone.0114198. eCollection 2014.
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