Adamopoulos Christos, Gargalionis Antonios N, Piperi Christina, Papavassiliou Athanasios G
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, 11527, Greece.
J Cell Biochem. 2017 Feb;118(2):232-236. doi: 10.1002/jcb.25660. Epub 2016 Aug 16.
Mechanotransduction is a key process by which cells perceive extracellular mechanical cues/intercellular physical interactions and transform them into intracellular biochemical signals. This physiological process is crucial during bone development and bone remodeling throughout childhood and adult life, whereas several aberrations during this process have emerged as a distinct pathogenic molecular entity in bone maladies and tumor formation. The present review focuses on recent advances regarding the mechanobiology of osteosarcoma, the most common type of bone cancer. Special emphasis is given on the mechano-responsive signal transduction pathways underlying osteosarcoma pathology and on specific mechanosensitive molecules engaged in osteosarcoma development. J. Cell. Biochem. 118: 232-236, 2017. © 2016 Wiley Periodicals, Inc.
机械转导是一个关键过程，通过该过程细胞感知细胞外机械信号/细胞间物理相互作用，并将其转化为细胞内生化信号。这一生理过程在儿童期和成年期的骨骼发育和骨重塑过程中至关重要，而在此过程中的几种异常情况已成为骨疾病和肿瘤形成中一种独特的致病分子实体。本综述重点关注骨肉瘤（最常见的骨癌类型）机械生物学的最新进展。特别强调了骨肉瘤病理学背后的机械反应信号转导途径以及参与骨肉瘤发展的特定机械敏感分子。《细胞生物化学杂志》118: 232 - 236, 2017。© 2016威利期刊公司。
