• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

TAB3通过与TAK1-TRAF6复合物结合上调Survivin表达，以促进结直肠癌的侵袭和转移。

TAB3 upregulates Survivin expression to promote colorectal cancer invasion and metastasis by binding to the TAK1-TRAF6 complex.

作者信息

Luo Chen, Yuan Rongfa, Chen Leifeng, Zhou Wei, Shen Wei, Qiu Yumin, Shao Jun, Yan Jinlong, Shao Jianghua

机构信息

Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.

Jiangxi Province Key Laboratory of Molecular Medicine, Nanchang 330006, China.

出版信息

Oncotarget. 2017 Nov 18;8(63):106565-106576. doi: 10.18632/oncotarget.22497. eCollection 2017 Dec 5.

DOI:10.18632/oncotarget.22497
PMID:29290971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5739756/
Abstract

Transforming growth factor-β-activated kinase 1 (TAK1)-binding protein 3 (TAB3) is involved in cancer proliferation and metastasis, but its role in colorectal cancer remains unclear. In this study, we demonstrated that TAB3 is upregulated in colorectal cancer tissues and that high TAB3 levels correlated with tumor metastasis and a poor prognosis in colorectal cancer. In addition, TAB3 knockdown decreased Survivin expression and suppressed colorectal cancer cell migration and invasion , and reduced liver metastasis . Importantly, we found that TAB3 regulated Survivin expression by activating the NF-κB pathway through the formation of the TAK1-TAB3-TRAF6 complex. These findings suggest TAB3 may be a useful prognostic biomarker in colorectal cancer and a target for treatment of metastatic colorectal cancer.

摘要

转化生长因子-β激活激酶1（TAK1）结合蛋白3（TAB3）参与癌症的增殖和转移，但其在结直肠癌中的作用尚不清楚。在本研究中，我们证明TAB3在结直肠癌组织中上调，且高TAB3水平与结直肠癌的肿瘤转移和不良预后相关。此外，敲低TAB3可降低生存素表达，抑制结直肠癌细胞的迁移和侵袭，并减少肝转移。重要的是，我们发现TAB3通过形成TAK1-TAB3-TRAF6复合物激活NF-κB信号通路来调节生存素表达。这些发现表明，TAB3可能是结直肠癌中一个有用的预后生物标志物，也是转移性结直肠癌治疗的一个靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ac/5739756/8efe1e65bdfd/oncotarget-08-106565-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ac/5739756/d181c173c571/oncotarget-08-106565-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ac/5739756/4673dbc405ff/oncotarget-08-106565-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ac/5739756/229d29e4f205/oncotarget-08-106565-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ac/5739756/1800bbb67ad3/oncotarget-08-106565-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ac/5739756/8efe1e65bdfd/oncotarget-08-106565-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ac/5739756/d181c173c571/oncotarget-08-106565-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ac/5739756/4673dbc405ff/oncotarget-08-106565-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ac/5739756/229d29e4f205/oncotarget-08-106565-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ac/5739756/1800bbb67ad3/oncotarget-08-106565-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ac/5739756/8efe1e65bdfd/oncotarget-08-106565-g005.jpg

相似文献

1
TAB3 upregulates Survivin expression to promote colorectal cancer invasion and metastasis by binding to the TAK1-TRAF6 complex.TAB3通过与TAK1-TRAF6复合物结合上调Survivin表达，以促进结直肠癌的侵袭和转移。
Oncotarget. 2017 Nov 18;8(63):106565-106576. doi: 10.18632/oncotarget.22497. eCollection 2017 Dec 5.
2
TAB3 upregulates PIM1 expression by directly activating the TAK1-STAT3 complex to promote colorectal cancer growth.TAB3 通过直接激活 TAK1-STAT3 复合物上调 PIM1 表达，从而促进结直肠癌生长。
Exp Cell Res. 2020 Jun 1;391(1):111975. doi: 10.1016/j.yexcr.2020.111975. Epub 2020 Mar 27.
3
TAB3 overexpression promotes cell proliferation in non-small cell lung cancer and mediates chemoresistance to CDDP in A549 cells via the NF-κB pathway.TAB3过表达促进非小细胞肺癌细胞增殖，并通过NF-κB途径介导A549细胞对顺铂的化疗耐药。
Tumour Biol. 2016 Mar;37(3):3851-61. doi: 10.1007/s13277-015-3896-y. Epub 2015 Oct 17.
4
Identification of a human NF-kappaB-activating protein, TAB3.一种人类NF-κB激活蛋白TAB3的鉴定。
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2028-33. doi: 10.1073/pnas.0307314101. Epub 2004 Feb 6.
5
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.TAB2相关蛋白TAB3在白细胞介素-1和肿瘤坏死因子信号传导中的作用。
EMBO J. 2003 Dec 1;22(23):6277-88. doi: 10.1093/emboj/cdg605.
6
Loss of TAB3 expression by shRNA exhibits suppressive bioactivity and increased chemical sensitivity of ovarian cancer cell lines via the NF-κB pathway.通过短发夹RNA（shRNA）使TAB3表达缺失，可通过核因子κB（NF-κB）途径表现出抑制性生物活性并增强卵巢癌细胞系的化学敏感性。
Cell Prolif. 2016 Dec;49(6):657-668. doi: 10.1111/cpr.12293. Epub 2016 Sep 21.
7
TAB3 O-GlcNAcylation promotes metastasis of triple negative breast cancer.TAB3的O-连接N-乙酰葡糖胺化促进三阴性乳腺癌的转移。
Oncotarget. 2016 Apr 19;7(16):22807-18. doi: 10.18632/oncotarget.8182.
8
Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2.Smad7与衔接蛋白TAB2和TAB3结合，以阻止激酶TAK1募集至衔接蛋白TRAF2。
Nat Immunol. 2007 May;8(5):504-13. doi: 10.1038/ni1451. Epub 2007 Mar 25.
9
Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs.通过 MAPKs 介导的 B 细胞激活中 K63 连接多泛素结合蛋白 TAB2 和 TAB3 的必需作用。
J Immunol. 2013 Apr 15;190(8):4037-45. doi: 10.4049/jimmunol.1300173. Epub 2013 Mar 15.
10
TAB3, a new binding partner of the protein kinase TAK1.TAB3，蛋白激酶TAK1的一种新的结合伴侣。
Biochem J. 2004 Feb 15;378(Pt 1):27-34. doi: 10.1042/BJ20031794.

引用本文的文献

1
PIM1 kinase and its diverse substrate in solid tumors.PIM1 激酶及其在实体瘤中的多种底物。
Cell Commun Signal. 2024 Nov 1;22(1):529. doi: 10.1186/s12964-024-01898-y.
2
Tumor Necrosis Factor Receptor-Associated Factor 6 and Human Cancer: A Systematic Review of Mechanistic Insights, Functional Roles, and Therapeutic Potential.肿瘤坏死因子受体相关因子6与人类癌症：关于机制见解、功能作用及治疗潜力的系统综述
J Cancer. 2024 Jan 1;15(2):560-576. doi: 10.7150/jca.90059. eCollection 2024.
3
miR‑27a‑3p upregulation by p65 facilitates cervical tumorigenesis by increasing TAB3 expression and is involved in the positive feedback loop of NF‑κB signaling.

本文引用的文献

1
Increased levels of LAPTM4B, VEGF and survivin are correlated with tumor progression and poor prognosis in breast cancer patients.LAPTM4B、VEGF和生存素水平升高与乳腺癌患者的肿瘤进展及不良预后相关。
Oncotarget. 2017 Jun 20;8(25):41282-41293. doi: 10.18632/oncotarget.17176.
2
NF-κB suppresses apoptosis and promotes bladder cancer cell proliferation by upregulating survivin expression in vitro and in vivo.NF-κB 通过上调生存素的表达在体内外抑制细胞凋亡并促进膀胱癌的增殖。
Sci Rep. 2017 Jan 31;7:40723. doi: 10.1038/srep40723.
3
Post-Translational Modifications of the TAK1-TAB Complex.
p65 上调 miR-27a-3p 促进 TAB3 表达从而促进宫颈癌发生，并且参与 NF-κB 信号的正反馈回路。
Oncol Rep. 2023 Jul;50(1). doi: 10.3892/or.2023.8569. Epub 2023 May 19.
4
Competitive Endogenous RNA Landscape in Epstein-Barr Virus Associated Nasopharyngeal Carcinoma.爱泼斯坦-巴尔病毒相关鼻咽癌中的竞争性内源性RNA图谱
Front Cell Dev Biol. 2021 Nov 4;9:782473. doi: 10.3389/fcell.2021.782473. eCollection 2021.
5
LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathway.LINC01094通过吸附miR-577来调节LIN28B表达及PI3K/AKT通路，从而促进胰腺癌进展。
Mol Ther Nucleic Acids. 2021 Aug 26;26:523-535. doi: 10.1016/j.omtn.2021.08.024. eCollection 2021 Dec 3.
6
TBC1D25 Regulates Cardiac Remodeling Through TAK1 Signaling Pathway.TBC1D25 通过 TAK1 信号通路调节心脏重构。
Int J Biol Sci. 2020 Feb 21;16(8):1335-1348. doi: 10.7150/ijbs.41130. eCollection 2020.
7
IFITM3 promotes hepatocellular carcinoma invasion and metastasis by regulating MMP9 through p38/MAPK signaling.干扰素诱导跨膜蛋白3（IFITM3）通过p38/丝裂原活化蛋白激酶（MAPK）信号通路调控基质金属蛋白酶9（MMP9），从而促进肝细胞癌的侵袭和转移。
FEBS Open Bio. 2018 Jun 28;8(8):1299-1311. doi: 10.1002/2211-5463.12479. eCollection 2018 Aug.
TAK1-TAB复合物的翻译后修饰
Int J Mol Sci. 2017 Jan 19;18(1):205. doi: 10.3390/ijms18010205.
4
Ubiquitin-like protein FAT10 promotes bladder cancer progression by stabilizing survivin.类泛素蛋白FAT10通过稳定生存素促进膀胱癌进展。
Oncotarget. 2016 Dec 6;7(49):81463-81473. doi: 10.18632/oncotarget.12976.
5
TAB3 O-GlcNAcylation promotes metastasis of triple negative breast cancer.TAB3的O-连接N-乙酰葡糖胺化促进三阴性乳腺癌的转移。
Oncotarget. 2016 Apr 19;7(16):22807-18. doi: 10.18632/oncotarget.8182.
6
The TGF-β pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cells.在耐药性结直肠癌细胞中，转化生长因子-β（TGF-β）信号通路被5-氟尿嘧啶治疗激活。
Oncotarget. 2016 Apr 19;7(16):22077-91. doi: 10.18632/oncotarget.7895.
7
Survivin and Tumorigenesis: Molecular Mechanisms and Therapeutic Strategies.Survivin 与肿瘤发生：分子机制与治疗策略。
J Cancer. 2016 Jan 10;7(3):314-23. doi: 10.7150/jca.13332. eCollection 2016.
8
MiR-30a attenuates immunosuppressive functions of IL-1β-elicited mesenchymal stem cells via targeting TAB3.微小RNA-30a通过靶向TAB3减弱白细胞介素-1β诱导的间充质干细胞的免疫抑制功能。
FEBS Lett. 2015 Dec 21;589(24 Pt B):3899-907. doi: 10.1016/j.febslet.2015.11.001. Epub 2015 Nov 7.
9
Inhibition of murine breast cancer growth and metastasis by survivin-targeted siRNA using disulfide cross-linked linear PEI.使用二硫键交联线性聚乙烯亚胺靶向survivin的小干扰RNA抑制小鼠乳腺癌的生长和转移
Eur J Pharm Sci. 2016 Jan 20;82:171-82. doi: 10.1016/j.ejps.2015.11.009. Epub 2015 Nov 7.
10
Rock2 stabilizes β-catenin to promote tumor invasion and metastasis in colorectal cancer.Rock2可稳定β-连环蛋白，以促进结直肠癌的肿瘤侵袭和转移。
Biochem Biophys Res Commun. 2015 Nov 27;467(4):629-37. doi: 10.1016/j.bbrc.2015.10.103. Epub 2015 Oct 23.