Zeng Yu Fan, Sang Jianfeng
From the Bachelor of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Department of General Surgery, Nanjing Drum Tower Hospital, Nanjing, China.
Oncotarget. 2017 Oct 7;8(63):107273-107282. doi: 10.18632/oncotarget.21620. eCollection 2017 Dec 5.
Some studies have reported an association between the zinc-finger protein 350 (ZNF350), also known as zinc-finger and BRCA1-interacting protein with a Kruppel-associated box (KRAB) domain (ZBRK1), and risks of breast cancer, although the results remain controversial. A systematic search was conducted on PubMed, Web of Science, EMBASE, Ovid, Chinese National Knowledge Databases, and WanFang databases with relevant keywords. Four studies of five distinct populations involving 5824 breast cancer cases were used to conduct a meta-analysis that summarizes the current evidence of 5 genetic polymorphisms: Asp35Asp, Leu66Pro, Pro373Pro, Ser472Pro, and Ser501Arg in the ZNF350 gene. The T allele in Asp35Asp polymorphisms not significantly associated with increased risk of breast cancer (OR: 1.08; 95% CI: 0.96-1.21). The minor C allele of the Asp35Asp polymorphism is protective in the overdominant model (OR = 1.14; 95% CI: 1.02-1.28). The Pro allele in the Leu66Pro polymorphism is protective in all of the models examined (allelic, dominant, recessive, and overdominant). The Pro373Pro is not associated with breast cancer in all of the models tested. The Pro allele of the Ser472Pro polymorphism is protective using the dominant model (OR = 0.10; 95% CI: 0.04-0.23) but deleterious using the overdominant model (OR = 1.14; 95% CI: 1.02-1.28). The Ser501Arg polymorphism is deleterious only when using the recessive model (OR = 1.21; 95% CI: 1.02-1.44). In conclusion, this meta-analysis suggests that genetic polymorphisms in the variant can increase, decrease, or have no effect on the risks of breast cancer depending on the polymorphism and genetic model used. Further studies will be required to validate these findings.
一些研究报告称，锌指蛋白350（ZNF350），也称为锌指与BRCA1相互作用蛋白且带有Kruppel相关盒（KRAB）结构域（ZBRK1），与乳腺癌风险之间存在关联，尽管结果仍存在争议。我们使用相关关键词在PubMed、科学网、EMBASE、Ovid、中国国家知识数据库和万方数据库中进行了系统检索。对涉及5824例乳腺癌病例的五个不同人群的四项研究进行了荟萃分析，总结了ZNF350基因中5种基因多态性（Asp35Asp、Leu66Pro、Pro373Pro、Ser472Pro和Ser501Arg）的现有证据。Asp35Asp多态性中的T等位基因与乳腺癌风险增加无显著关联（比值比：1.08；95%置信区间：0.96 - 1.21）。Asp35Asp多态性的次要C等位基因在超显性模型中具有保护作用（比值比 = 1.14；95%置信区间：1.02 - 1.28）。Leu66Pro多态性中的Pro等位基因在所有检测模型（等位基因、显性、隐性和超显性）中均具有保护作用。Pro373Pro在所有测试模型中均与乳腺癌无关。Ser472Pro多态性的Pro等位基因在显性模型中具有保护作用（比值比 = 0.10；95%置信区间：0.04 - 0.23），但在超显性模型中具有有害作用（比值比 = 1.14；95%置信区间：1.02 - 1.28）。Ser501Arg多态性仅在使用隐性模型时具有有害作用（比值比 = 1.21；95%置信区间：1.02 - 1.44）。总之，这项荟萃分析表明，该变体中的基因多态性根据所使用的多态性和遗传模型，可能会增加、降低或对乳腺癌风险没有影响。需要进一步的研究来验证这些发现。
