烷基链长度和不饱和度对姜黄素与吐温胶束疏水结合的影响。
Effects of length and unsaturation of the alkyl chain on the hydrophobic binding of curcumin with Tween micelles.
机构信息
School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.
School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.
出版信息
Food Chem. 2018 Apr 25;246:242-248. doi: 10.1016/j.foodchem.2017.11.024. Epub 2017 Nov 8.
This work studies the effects of length and unsaturation of alkyl chain on the hydrophobic binding of curcumin with Tween 20, 60 and 80 micelles. While Tween 20 and 60 possess 12 and 18 saturated carbons, respectively, in their alkyl chains, the alkyl chain of Tween 80, with one double bond, has the same length as Tween 60. Tween 60 micelles are superior to Tween 20 and 80 micelles for improving curcumin stability. The fluorescence measurement suggests that Tween 60 micelles provide curcumin with the most hydrophobic microenvironment, owing to the long and saturated alkyl chain of Tween 60. The pK and binding constants of curcumin have the same order of Tween 60 > Tween 20 > Tween 80. These results show that the length increase, and unsaturation, of the alkyl chain of Tween surfactants have opposite effects on the hydrophobic binding of curcumin with Tween micelles.
这项工作研究了烷基链的长度和不饱和度对姜黄素与吐温 20、60 和 80 胶束疏水性结合的影响。虽然吐温 20 和 60 的烷基链中分别含有 12 和 18 个饱和碳原子，但含有一个双键的 Tween 80 烷基链与 Tween 60 的长度相同。与 Tween 20 和 80 胶束相比，Tween 60 胶束更能提高姜黄素的稳定性。荧光测量表明，由于 Tween 60 的长而饱和的烷基链，Tween 60 胶束为姜黄素提供了最疏水的微环境。姜黄素的 pK 和结合常数的顺序为 Tween 60 > Tween 20 > Tween 80。这些结果表明，吐温表面活性剂烷基链的长度增加和不饱和度对姜黄素与吐温胶束的疏水性结合有相反的影响。
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