Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China; Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou 730000, China; Chinese GRADE Center, Lanzhou 730000, China.
Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China; Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou 730000, China; Chinese GRADE Center, Lanzhou 730000, China.
J Clin Epidemiol. 2018 Jun;98:1-8. doi: 10.1016/j.jclinepi.2017.12.021. Epub 2017 Dec 30.
We aimed to examine the declaration of interests (DOIs), management of conflict of interest (COI), and the funders for World Health Organization (WHO) guidelines.
We examined all Guidelines Review Committee (GRC)-approved WHO guidelines published in English from January 2007 (inception of the GRC) to November 2016. We obtained a list of all such guidelines from the GRC Secretariat. Characteristics of guidelines including funders and individual contributors' DOI were independently extracted by two researchers. Binary logistic regression was used to assess the association between declarations and the number of organizations involved in development.
A total of 176 guidelines fulfilled inclusion criteria, encompassing 14 clinical or public health fields. Funders were reported in 128 (73%) of the guidelines: the most common were governments. DOI for external contributors were reported in 157 (89%) of the guidelines: 75 (48%) indicated no contributors with COI, 57 (36%) reported contributors with COI, and 25 (16%) reported collecting DOI but not whether COI existed. Financial COI were reported more frequently than nonfinancial COI. Of 57 guidelines that reported COI, 45 (79%) indicated how the COI were managed.
The majority of WHO guidelines reported their funding sources and the DOI and COI of external contributors in their guideline documents. However, there is a need for improvement, in particular for reporting of funders and their role, declaration processes, and management of COI.
我们旨在检查利益声明（DOI）、利益冲突（COI）管理以及世界卫生组织（WHO）指南的资助者。
我们检查了所有 2007 年 1 月（GRC 成立）至 2016 年 11 月批准的由 WHO 指南审查委员会（GRC）批准的英文指南。我们从 GRC 秘书处获得了所有此类指南的列表。由两名研究人员独立提取指南的特征，包括资助者和个人贡献者的 DOI。二项逻辑回归用于评估声明与参与制定的组织数量之间的关联。
共有 176 项符合纳入标准的指南，涵盖 14 个临床或公共卫生领域。128 项（73%）指南报告了资助者：最常见的是政府。157 项（89%）指南报告了外部贡献者的 DOI：75 项（48%）表示没有利益冲突的贡献者，57 项（36%）报告了有利益冲突的贡献者，25 项（16%）报告了收集 DOI 但未报告是否存在利益冲突。财务利益冲突的报告频率高于非财务利益冲突。在报告 COI 的 57 项指南中，45 项（79%）表明了如何管理 COI。
大多数 WHO 指南在其指南文件中报告了资金来源以及外部贡献者的 DOI 和 COI。然而，需要改进，特别是报告资助者及其角色、申报流程和 COI 的管理。
