School of Chinese Medicine, Changchun University of Chinese Medicine, Changchun Jilin, 130117, China.
Pediatric Department, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun Jilin, 130021, China.
BMC Pregnancy Childbirth. 2024 Mar 7;24(1):184. doi: 10.1186/s12884-024-06377-3.
At present, the need for vitamin C supplementation for pregnant smokers has not been fully studied. This study is aimed at investigating whether vitamin C supplementation for pregnant smoking women can improve the pulmonary function of their offspring.
Four databases were searched from inception to April 1, 2023 for studies on the effect of vitamin C supplementation to pregnant smokers on the pulmonary function of their offspring. Meanwhile, the reference lists of relevant studies were manually searched. The risk of bias in the included studies was assessed using the Cochrane Collaboration tool, and the data was analyzed using STATA/SE 17.0.
Four randomized controlled trials (RCTs), all of high quality, were enrolled in this meta-analysis, including 787 pregnant women. The offspring of pregnant smokers who received vitamin C supplementation exhibited improved Forced Expiratory Flow between 25 and 75% (FEF25-75), FEF50, FEF75, and Forced Vital Capacity (FVC) compared to those who did not receive vitamin C supplementation. However, there was no statistically significant difference in Forced Expiratory Volume at 0.5 s (FEV0.5) and the ratio of FEV0.5 to FVC between the offspring of pregnant smokers who received vitamin C and the control group.
Vitamin C supplementation for smoking pregnant women may enhance the pulmonary function of their offspring, particularly in FEF25-75, FEF50, FEF75, and FVC. Nevertheless, there are no significant differences in FEV0.5 and the FEV0.5/FVC ratio. These findings suggest that vitamin C supplementation has potential benefits for specific pulmonary function. Further studies are needed to comprehensively assess the effects of vitamin C on pulmonary function in the context of maternal smoking during pregnancy.
目前，关于补充维生素 C 对吸烟孕妇的需求尚未得到充分研究。本研究旨在探讨补充维生素 C 是否可以改善吸烟孕妇后代的肺功能。
从建库到 2023 年 4 月 1 日，在四个数据库中检索关于补充维生素 C 对吸烟孕妇后代肺功能影响的研究。同时，手动检索相关研究的参考文献列表。使用 Cochrane 协作工具评估纳入研究的偏倚风险，并使用 STATA/SE 17.0 分析数据。
共有四项高质量的随机对照试验（RCT）被纳入本荟萃分析，共纳入 787 名孕妇。与未接受维生素 C 补充的孕妇相比，接受维生素 C 补充的吸烟孕妇的后代用力呼出 25%至 75%肺活量时的流速（FEF25-75）、FEF50、FEF75 和用力肺活量（FVC）均有所提高。但在第 0.5 秒用力呼气量（FEV0.5）和 FEV0.5/FVC 比值方面，接受维生素 C 补充的吸烟孕妇与对照组的后代之间没有统计学差异。
补充维生素 C 可能会增强吸烟孕妇后代的肺功能，尤其是 FEF25-75、FEF50、FEF75 和 FVC。然而，在 FEV0.5 和 FEV0.5/FVC 比值方面，并无显著差异。这些发现表明，维生素 C 补充对特定的肺功能具有潜在益处。需要进一步的研究来全面评估维生素 C 对母亲吸烟期间胎儿肺功能的影响。
