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伴 Doege-Potter 综合征的转移性孤立性纤维性肿瘤:90Y 放射性栓塞治疗低血糖。

Metastatic Solitary Fibrous Tumor With Doege-Potter Syndrome: Hypoglycemia Treated by 90Y Radioembolization.

出版信息

Clin Nucl Med. 2018 Mar;43(3):e93-e95. doi: 10.1097/RLU.0000000000001944.

Abstract

Solitary fibrous tumor is a rare type of mesenchymal neoplasm that can be associated to a paraneoplastic severe hypoglycemia due to the overproduction of insulinlike growth factor type 2: Doege-Potter syndrome. When surgical resection is impossible or unsuccessful, alternative therapies were described with heterogeneous efficiency. We report the use of radioembolization with Y-labeled glass microspheres in this application. Regarding the excellent results obtained and the potential interest of peptide receptor radionuclide therapy suggested by overexpression of somatostatin receptors in our patient, the place of targeted radionuclide therapies deserves to be explored in this group of tumors.

摘要

孤立性纤维瘤是一种罕见的间叶性肿瘤,由于胰岛素样生长因子 2 的过度产生,可与副肿瘤性严重低血糖相关:Doege-Potter 综合征。当手术切除不可能或不成功时,曾描述过各种不同效果的替代疗法。我们报告了在这种情况下使用 Y 标记的玻璃微球进行放射性栓塞。鉴于我们患者中生长抑素受体的过度表达提示肽受体放射性核素治疗具有良好的效果和潜在的应用前景,针对这类肿瘤的靶向放射性核素治疗的地位值得探讨。

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