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针对肝转移性孤立性纤维瘤继发非胰岛细胞瘤低血糖症的瘤内乳酸酸中毒经动脉化疗栓塞术:病例报告及文献综述

Targeting-intratumoral-lactic-acidosis transcatheter-arterial-chemoembolization for non-islet cell tumor hypoglycemia secondary to a liver metastatic solitary fibrous tumor: A case report and literature review.

作者信息

Jin Kai, Zhong Shan, Lin Liya, Wu Jianjun, Wang Yuqi, Cui Weijuan, Gu Wei, Chao Ming, Song Xiaoxiao

机构信息

Department of Radiology, The Second Affiliated Hospital School of Medicine, Zhejiang University School of Medicine, Hangzhou, China.

Department of Endocrine and Metabolic Diseases, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

出版信息

Front Endocrinol (Lausanne). 2022 Aug 11;13:955687. doi: 10.3389/fendo.2022.955687. eCollection 2022.

Abstract

Doege-Potter syndrome is a rare paraneoplastic syndrome characterized by non-islet cell tumor hypoglycemia secondary to a solitary fibrous tumor. Doege-Potter syndrome always presents with recurrent fasting hypoglycemia, which can occasionally be life-threatening. The best choice of treatment for Doege-Potter syndrome and solitary fibrous tumor is complete resection. However, when it is unfeasible, local-regional treatment can be used as a palliative therapy. Herein, we report a case of a 46-year-old man with Doege-Potter syndrome that occurred secondary to the liver and pancreatic metastatic solitary fibrous tumors. After he received six rounds of targeting-intratumoral-lactic-acidosis transcatheter-arterial-chemoembolization (TILA-TACE) treatment in our hospital, his hypoglycemia was clinically cured, and the liver metastatic tumor was well controlled. We suggest that TILA-TACE can be considered when curative resection is unfeasible for metastatic liver solitary fibrous tumors to help a patient obtain further surgery opportunities.

摘要

多伊奇-波特综合征是一种罕见的副肿瘤综合征,其特征为继发于孤立性纤维瘤的非胰岛细胞瘤性低血糖症。多伊奇-波特综合征总是表现为反复空腹低血糖,偶尔可能危及生命。多伊奇-波特综合征和孤立性纤维瘤的最佳治疗选择是完整切除。然而,当无法进行完整切除时,局部区域治疗可作为姑息治疗。在此,我们报告一例46岁男性患者,其多伊奇-波特综合征继发于肝脏和胰腺转移性孤立性纤维瘤。在我院接受六轮靶向肿瘤内乳酸酸中毒经导管动脉化疗栓塞术(TILA-TACE)治疗后,其低血糖症临床治愈,肝转移瘤得到良好控制。我们建议,对于转移性肝脏孤立性纤维瘤无法进行根治性切除时,可考虑TILA-TACE,以帮助患者获得进一步的手术机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed06/9403894/e8a1ae97d4aa/fendo-13-955687-g001.jpg

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