Clin Nucl Med. 2018 Mar;43(3):e101-e102. doi: 10.1097/RLU.0000000000001962.
Esthesioneuroblastoma is a rare neuroectodermic tumor of the olfactory tract. An F-FDG PET/CT was performed in a 75-year-old woman with cervical lymphadenopathy. It demonstrated focal intense uptake (SUVmax, 72 g/mL) in an occult sphenoclival tumor. Anatomopathological examination of the lymphadenopathy and the primary tumor biopsy revealed well-differentiated esthesioneuroblastoma. Explaining the paradox between tumor differentiation and PET findings, immunohistochemistry showed low Ki-67 but overexpression of GLUT-1 suggesting an activation of hypoxia pathways. Unlike many solid tumors, FDG avidity is not correlated with histological grade in esthesioneuroblastoma. The tumor biology may clarify the discrepancy between metabolic activity and cellular mitotic processes.
嗅神经母细胞瘤是一种罕见的发生于嗅道的神经外胚层肿瘤。对一名 75 岁有颈部淋巴结病的女性进行了 F-FDG PET/CT 检查。结果显示在隐匿的蝶枕部肿瘤中有局灶性浓聚（SUVmax，72 g/mL）。对淋巴结病和原发肿瘤活检的解剖病理学检查显示为分化良好的嗅神经母细胞瘤。免疫组化显示 Ki-67 低表达但 GLUT-1 过表达，提示缺氧途径激活，这解释了肿瘤分化与 PET 结果之间的矛盾。与许多实体瘤不同，FDG 摄取与嗅神经母细胞瘤的组织学分级无关。肿瘤生物学可能阐明代谢活性与细胞有丝分裂过程之间的差异。
