硼替佐米治疗难治性免疫性血小板减少性紫癜。
Bortezomib for Refractory Immune-Mediated Thrombocytopenia Purpura.
机构信息
Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC.
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC.
出版信息
Am J Ther. 2018 Mar/Apr;25(2):e270-e272. doi: 10.1097/MJT.0000000000000517.
Abstract
The treatment of refractory immune-mediated thrombocytopenia purpura (ITP) can be challenging. This case report describes treatment of refractory ITP with bortezomib, a proteasome inhibitor. This strategy has been successful in relapsing thrombotic thrombocytopenic purpura but is a novel therapeutic approach for ITP. Further research use of proteasome inhibition in refractory ITP may be warranted.
摘要
治疗难治性免疫介导的血小板减少性紫癜（ITP）可能具有挑战性。本病例报告描述了使用蛋白酶体抑制剂硼替佐米治疗难治性 ITP。这种策略在复发性血栓性血小板减少性紫癜中是成功的，但对于 ITP 是一种新的治疗方法。进一步研究蛋白酶体抑制在难治性 ITP 中的应用可能是有必要的。
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本文引用的文献
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Bortezomib induces clinical remission and reduction of ADAMTS13 inhibitory antibodies in relapsed refractory idiopathic thrombotic thrombocytopenic purpura.硼替佐米可诱导复发难治性特发性血栓性血小板减少性紫癜患者临床缓解并降低ADAMTS13抑制性抗体水平。
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