Denardi Laura Bedin, Oliveira Vanessa, de Jesus Francielli Pantella Kunz, Dalla-Lana Bianca Hoch, Santurio Janio Morais, Zanette Régis Adriel, Alves Sydney Hartz
Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.
Laboratório de Pesquisas Micológicas, Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.
Med Mycol. 2018 Nov 1;56(8):1006-1011. doi: 10.1093/mmy/myx159.
Combinations of an azole (itraconazole, voriconazole, or posaconazole) with an echinocandin (caspofungin, micafungin, or anidulafungin) were tested against 20 clinical isolates of Aspergillus flavus according to EUCAST guidelines. The interactions were determined using two endpoints-minimal effective concentration (MEC) and minimal inhibitory concentration (MIC)-via calculation of the fractional inhibitory concentration (FIC) index. A higher prevalence of synergistic interactions was observed for MIC, whereas indifference was the most frequent outcome according to MEC among the 20 strains. Combined treatment of A. flavus with these two important classes of antifungals should be explored further in in vivo studies.
根据欧洲抗菌药物敏感性试验委员会（EUCAST）指南，对20株黄曲霉临床分离株测试了唑类药物（伊曲康唑、伏立康唑或泊沙康唑）与棘白菌素类药物（卡泊芬净、米卡芬净或阿尼芬净）的联合用药效果。通过计算部分抑菌浓度（FIC）指数，使用两个终点指标——最低有效浓度（MEC）和最低抑菌浓度（MIC）来确定相互作用。对于MIC，观察到协同相互作用的发生率更高，而根据MEC，在这20株菌株中无明显作用是最常见的结果。这两类重要抗真菌药物联合治疗黄曲霉的方法应在体内研究中进一步探索。
