Shiffman M L, Seale T W, Flux M, Rennert O R, Swender P T
Robert C. Schwartz Cystic Fibrosis Center, Department of Pediatrics, State University of New York Update Medical Center, Syracuse.
Am J Clin Nutr. 1989 Apr;49(4):612-7. doi: 10.1093/ajcn/49.4.612.
Breast milk was collected from two women with cystic fibrosis (CF) and data from the literature was reviewed. The sodium concentration was within normal limits, 11-24 mmol/L in colostrum and 7-8 mmol/L in mature milk. Normal physiologic changes in milk composition after parturition (decreases in Na and increases in lactose) and during individual feeding periods (increases in fat and decreases in protein) were observed. Concentrations of milk protein, fat, and sugars were normal when the pulmonary disease of these patients was mild. During exacerbations of pulmonary disease, the concentrations of milk macronutrients were reduced. Milk secreted by women with CF appears to be physiologically normal, safe for the infant, and breast-feeding by mothers with CF should no longer be discouraged. Variations in the macronutrient content of CF milk warrants routine monitoring of the mother with CF and the breast-fed infant, especially during exacerbations in the pulmonary aspects of this disease.
收集了两名囊性纤维化（CF）女性的母乳，并对文献数据进行了回顾。钠浓度在正常范围内，初乳中为11 - 24 mmol/L，成熟乳中为7 - 8 mmol/L。观察到产后母乳成分的正常生理变化（钠减少，乳糖增加）以及个体喂养期间的变化（脂肪增加，蛋白质减少）。当这些患者的肺部疾病较轻时，母乳中蛋白质、脂肪和糖的浓度正常。在肺部疾病加重期间，母乳中常量营养素的浓度降低。CF女性分泌的母乳在生理上似乎是正常的，对婴儿是安全的，不应再劝阻CF母亲进行母乳喂养。CF母乳中常量营养素含量的变化值得对CF母亲和母乳喂养的婴儿进行常规监测，尤其是在该疾病肺部症状加重期间。
