Ohnishi K, Sato S, Nomura F, Iida S
First Department of Medicine, Chiba University School of Medicine, Japan.
Am J Gastroenterol. 1989 Apr;84(4):403-8.
A comparative study of splanchnic hemodynamics was made in 12 patients with idiopathic portal hypertension and in eight patients with chronic persistent hepatitis, but without portal hypertension, who served as the control. Venous pressures were measured by portal and hepatic vein catheterizations, blood flow by the pulsed Doppler flowmeter, and organ volume by computed tomography. Splenic artery blood flow was 788 +/- 242 ml/min in idiopathic portal hypertension and about four times that in chronic persistent hepatitis (215 +/- 42 ml/min), whereas there was no difference in superior mesenteric artery blood flow between the former and the latter (408 +/- 142 vs. 389 +/- 32 ml/min). Spleen volume in idiopathic portal hypertension was six times that in chronic persistent hepatitis, and splenic artery blood flow showed a significant linear correlation with spleen volume in idiopathic portal hypertension (r = 0.71, p less than 0.02). The sum of splenic artery blood flow and superior mesenteric artery blood flow in idiopathic portal hypertension was 1195 +/- 294 ml/min, twice that in chronic persistent hepatitis (603 +/- 109 ml/min). Portal vascular resistance and intrahepatic portal vascular resistance were three times and four times those in chronic persistent hepatitis, respectively. These results indicate that both increased intrahepatic portal vascular resistance and increased splenic artery blood flow may play roles in the development of portal hypertension in idiopathic portal hypertension.
对12例特发性门静脉高压患者和8例慢性持续性肝炎但无门静脉高压患者（作为对照）进行了内脏血流动力学的比较研究。通过门静脉和肝静脉插管测量静脉压力，用脉冲多普勒流量计测量血流，用计算机断层扫描测量器官体积。特发性门静脉高压患者的脾动脉血流量为788±242毫升/分钟，约为慢性持续性肝炎患者（215±42毫升/分钟）的四倍，而两者的肠系膜上动脉血流量无差异（分别为408±142与389±32毫升/分钟）。特发性门静脉高压患者的脾脏体积是慢性持续性肝炎患者的六倍，且特发性门静脉高压患者的脾动脉血流量与脾脏体积呈显著线性相关（r = 0.71，p＜0.02）。特发性门静脉高压患者的脾动脉血流量与肠系膜上动脉血流量之和为1195±294毫升/分钟，是慢性持续性肝炎患者（603±109毫升/分钟）的两倍。门静脉血管阻力和肝内门静脉血管阻力分别是慢性持续性肝炎患者的三倍和四倍。这些结果表明，肝内门静脉血管阻力增加和脾动脉血流量增加可能在特发性门静脉高压的门静脉高压形成中起作用。
