食物生物活性成分及其对肥胖加速型炎症性肠病的影响。

Food Bioactives and Their Effects on Obesity-Accelerated Inflammatory Bowel Disease.

作者信息

Chiou Yi-Shiou, Lee Pei-Sheng, Pan Min-Hsiung

机构信息

Institute of Food Science and Technology, National Taiwan University , Taipei 10617, Taiwan.

Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Hubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains, Huanggang Normal University , Huanggang, Hubei 438000, People's Republic of China.

出版信息

J Agric Food Chem. 2018 Jan 31;66(4):773-779. doi: 10.1021/acs.jafc.7b05854. Epub 2018 Jan 17.

DOI:10.1021/acs.jafc.7b05854

PMID:29295622

Abstract

Current views support the concept that obesity is linked to a worsening of the course of inflammatory bowel diseases (IBDs). Gut microbiota and adipose tissue macrophage (ATM) are considered key mediators or contributors in obesity-associated intestinal inflammation. Dietary components can have direct or indirect effects on "normal" or "healthy" microbial composition and participate in adiposity and metabolic status with gut inflammation. In this perspective, we highlight food-derived bioactives that have a potential application in the prevention of obesity-exacerbated IBD, targeting energy metabolism, M1 (classical activated)-M2 (alternatively activated) macrophage polarization, and gut microbiota.

摘要

当前观点支持肥胖与炎症性肠病（IBD）病情恶化相关的概念。肠道微生物群和脂肪组织巨噬细胞（ATM）被认为是肥胖相关肠道炎症的关键介质或促成因素。饮食成分可对“正常”或“健康”的微生物组成产生直接或间接影响，并通过肠道炎症参与肥胖和代谢状态。从这个角度来看，我们重点介绍了源自食物的生物活性物质，这些物质在预防肥胖加剧的IBD方面具有潜在应用价值，其作用靶点包括能量代谢、M1（经典活化）-M2（交替活化）巨噬细胞极化和肠道微生物群。