Jenkins Taylor M, Morrissette Jennifer J D, Kucharczuk John C, Deshpande Charuhas G
1 Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Int J Surg Pathol. 2018 Jun;26(4):360-363. doi: 10.1177/1066896917749928. Epub 2018 Jan 2.
Classic biphasic pulmonary blastoma (CBPB) is a rare and aggressive type of non-small cell lung carcinoma (NSCLC) presenting in adults in the fourth to fifth decade. The prognosis is poor and after surgical resection, therapeutic options are often limited. ROS1 is a proto-oncogene receptor tyrosine kinase that has been identified in some types of NSCLC. We report a case of a 36-year-old woman with CBPB, which was subsequently found to have a ROS1 rearrangement. This is the first reported case of a ROS1-rearranged CBPB. This finding has therapeutic implications as these tumors have the potential to be treated with receptor tyrosine kinase inhibitors.
经典双相肺母细胞瘤（CBPB）是一种罕见且侵袭性强的非小细胞肺癌（NSCLC），多见于40至50岁的成年人。其预后较差，手术切除后治疗选择往往有限。ROS1是一种原癌基因受体酪氨酸激酶，已在某些类型的NSCLC中被发现。我们报告了一例36岁患有CBPB的女性病例，该病例随后被发现存在ROS1重排。这是首例报告的ROS1重排的CBPB病例。这一发现具有治疗意义，因为这些肿瘤有可能用受体酪氨酸激酶抑制剂进行治疗。
