Di Lorenzo Gabriele, Di Bona Danilo, Belluzzo Federica, Macchia Luigi
Dipartimento BioMedico di Medicina Interna e Specialistica (Di.Bi.M.I.S.), Università di Palermo, Palermo, Italy.
Dipartimento BioMedico di Medicina Interna e Specialistica (Di.Bi.M.I.S), Via del Vespro, 141, 90127 Palermo, Italy.
Immun Ageing. 2017 Dec 20;14:23. doi: 10.1186/s12979-017-0105-4. eCollection 2017.
A better hygiene, a Westernized diet, air pollution, climate changes, and other factors that influence host microbiota, a key player in the induction and maintenance of immunoregulatory circuits and tolerance, are thought to be responsible for the increase of allergic diseases observed in the last years. The increase of allergic diseases in elderly is related to the presence of other factors as several comorbidities that should interfere with the development and the type of allergic reactions. A central role is played by immunosenescence responsible for modifying response to microbiota and triggering inflamm-ageing. In addition, in elderly there is a shift from Th1 responses vs. Th2, hence favouring allergic responses. Better understanding of the mechanisms of immunosenescence and its effects on allergic inflammation will most certainly lead to improved therapy.
更好的卫生条件、西化饮食、空气污染、气候变化以及其他影响宿主微生物群的因素被认为是近年来过敏性疾病增加的原因，而宿主微生物群是免疫调节回路和耐受性诱导与维持的关键因素。老年人过敏性疾病的增加与其他因素有关，比如一些会干扰过敏反应发生和类型的合并症。免疫衰老起着核心作用，它负责改变对微生物群的反应并引发炎症衰老。此外，老年人存在从Th1反应向Th2反应的转变，从而有利于过敏反应。更好地理解免疫衰老机制及其对过敏性炎症的影响肯定会带来更好的治疗效果。
