Abdalla Ahmed, Saifullah Shaik Mohamed, Osman Mohamed, Baniya Ramkaji, Sidahmed Shima, LaChance Jenny, Bachuwa Ghassan
Department of Internal Medicine, Hurley Medical Center, Michigan State University, College of Human Medicine, Flint, MI, USA.
Hematology/oncology attending, Hurley Medical Center, Michigan State University, College of Human Medicine, Flint, MI, USA.
J Community Hosp Intern Med Perspect. 2017 Dec 14;7(6):347-350. doi: 10.1080/20009666.2017.1396169. eCollection 2017.
: The prevalence of celiac disease (CD) in patients with iron deficiency (ID) is estimated at 0-6% in European countries. The prevalence of celiac disease in patients with iron deficiency in the USA is unknown. Given the treatable nature of gluten hypersensitivity, estimating the prevalence of CD in patients with ID can help to determine the need to screen these patients for occult CD. : Data were obtained from the NHANES database, a nationally representative health survey conducted from 2009 to 2010. We included 2,105 females aged 6 years or older. Iron deficiency was defined as serum ferritin level <20 ng/ml and considered positive for celiac disease when subjects were tested positive for both immunoglobulin A (IgA) tissue transglutaminase antibody and IgA endomysial antibody. Subjects were divided between two groups (ID and non-ID). The association of CD and ID, which was the primary outcome, was obtained after adjusting for other covariates using logistic regression. : Among the sample of 2,105 subjects, 569 had ID and 1536 did not have ID. Five people were identified as having CD among the ID group, as were two people in the non-ID group. After adjusting for selected covariates, the prevalence of CD was higher in female subjects with ID with OR of 12.5 (95% CI 1.74-90). : The overall prevalence of celiac disease in the USA' female population is low, however, the prevalence is higher in subjects with iron deficiency. Further prospective studies are needed to validate our findings.
在欧洲国家，缺铁（ID）患者中乳糜泻（CD）的患病率估计为0%-6%。美国缺铁患者中乳糜泻的患病率尚不清楚。鉴于麸质过敏具有可治疗性，估计缺铁患者中乳糜泻的患病率有助于确定对这些患者进行隐匿性乳糜泻筛查的必要性。：数据来自2009年至2010年进行的具有全国代表性的健康调查——美国国家健康与营养检查调查（NHANES）数据库。我们纳入了2105名6岁及以上的女性。缺铁定义为血清铁蛋白水平<20 ng/ml，当受试者免疫球蛋白A（IgA）组织转谷氨酰胺酶抗体和IgA肌内膜抗体检测均呈阳性时，则被认为乳糜泻检测呈阳性。受试者被分为两组（缺铁组和非缺铁组）。使用逻辑回归对其他协变量进行调整后，得出了作为主要结果的乳糜泻与缺铁之间的关联。：在2105名受试者样本中，569人缺铁，1536人不缺铁。缺铁组中有5人被确定患有乳糜泻，非缺铁组中有2人被确定患有乳糜泻。在对选定的协变量进行调整后，缺铁女性受试者中乳糜泻的患病率更高，比值比为12.5（95%置信区间1.74-90）。：美国女性人群中乳糜泻的总体患病率较低，然而，缺铁受试者中的患病率较高。需要进一步的前瞻性研究来验证我们的发现。
