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GL-V9, a new synthetic flavonoid derivative, ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1 expression via activation of AMPK/FOXO3a pathway.新型合成类黄酮衍生物GL-V9通过激活AMPK/FOXO3a途径上调Trx-1表达，减轻DSS诱导的结肠炎氧化应激。
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CaMKIα regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation.钙调蛋白依赖性激酶 α 调控脂多糖诱导的急性肺中性粒细胞炎症中 AMP 激酶依赖性、TORC1 非依赖性自噬。
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小分子GL-V9通过自噬限制NLRP3炎性小体，从而预防结肠炎相关的结直肠癌。

Small molecule GL-V9 protects against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.

作者信息

Zhao Yue, Guo Qinglong, Zhao Kai, Zhou Yuxin, Li Wenjun, Pan Chuyue, Qiang Lei, Li Zhiyu, Lu Na

机构信息

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, China.

Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL USA.

出版信息

Oncoimmunology. 2017 Sep 21;7(1):e1375640. doi: 10.1080/2162402X.2017.1375640. eCollection 2017.

DOI:10.1080/2162402X.2017.1375640
PMID:29296531
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5739552/
Abstract

Emerging evidence suggests that NLRP3 inflammasome provides a link between colitis-associated colorectal cancer and inflammatory bowel diseases. Autophagy is induced in macrophages by AMPK activation and regulates NLRP3 inflammasome to maintain intracellular homeostasis. Here we report that a small-molecule AMPK activator (GL-V9) exerts potent anti-inflammatory effects on macrophages and , which trigger autophagy to degraded NLRP3 inflammasome. Treatment with GL-V9 protected against colitis and tumorigenesis in colitis-associated colorectal cancer. This suggests that GL-V9 may be an interesting candidate for clinical evaluation in the treatment of colitis-associated colorectal cancer.

摘要

新出现的证据表明，NLRP3炎性小体在结肠炎相关的结直肠癌和炎症性肠病之间建立了联系。自噬由AMPK激活在巨噬细胞中诱导产生，并调节NLRP3炎性小体以维持细胞内稳态。在此，我们报告一种小分子AMPK激活剂（GL-V9）对巨噬细胞具有强大的抗炎作用，巨噬细胞触发自噬以降解NLRP3炎性小体。用GL-V9治疗可预防结肠炎相关结直肠癌中的结肠炎和肿瘤发生。这表明GL-V9可能是治疗结肠炎相关结直肠癌临床评估中一个有吸引力的候选药物。