间质性肺病与死亡率风险：一项为期 11 年的全国范围基于人群的研究。

Interstitial lung disease and risk of mortality: 11-year nationwide population-based study.

机构信息

Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Republic of Korea.

Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Republic of Korea, Department of Allergology, Hospital Serive of Kavaje, Albania.

出版信息

Int J Tuberc Lung Dis. 2018 Jan 1;22(1):100-105. doi: 10.5588/ijtld.17.0167.

DOI:10.5588/ijtld.17.0167

PMID:29297433

Abstract

BACKGROUND

Patients with interstitial lung disease (ILD) constitute a substantial disease burden. Although ILD outcomes have been investigated, the risk of death due to ILD has not been studied in the light of confounders and comorbidities. In this nationwide, 11-year longitudinal, population-based study, we aimed to discover if ILD is an independent risk factor for mortality.

DESIGN

Data on 1 031 392 (2.2%) randomly selected subjects from 47 279 373 Korean residents were collected from the 2002 Korean National Health Insurance database. The ILD group comprised patients with an initial diagnosis of ILD between January 2003 and December 2007. Each patient was followed until 2013. We used Cox proportional hazard regression analyses to calculate the risk of death adjusted for comorbidities and confounders.

RESULTS

ILD developed in 783 of the 303 385 subjects during the 5-year period (51 per 100 000 person-years). Death occurred in 157 (23.2%) cases and 272 controls (10.4%). ILD was significantly associated with the risk of death (hazard ratio 2.1, 95% confidence interval [CI] 1.6-2.7) and for those aged 40-59, 60-69 and 70 years. A high proportion of patients with ILD died due to respiratory causes.

CONCLUSION

ILD patients had a significantly higher risk of death than matched controls, after adjustment for potential confounders and comorbidities.

摘要

背景

间质性肺疾病（ILD）患者构成了相当大的疾病负担。尽管已经研究了ILD 的结局，但尚未根据混杂因素和合并症研究ILD 导致死亡的风险。在这项全国性的、11 年的纵向、基于人群的研究中，我们旨在发现ILD 是否是死亡的独立危险因素。

设计

从 47279373 名韩国居民的 2002 年韩国国家健康保险数据库中收集了 1031392（2.2%）名随机选择的受试者的数据。ILD 组包括 2003 年 1 月至 2007 年 12 月期间首次诊断为 ILD 的患者。每位患者均随访至 2013 年。我们使用 Cox 比例风险回归分析来计算调整混杂因素和混杂因素后的死亡风险。

结果

在 5 年期间，303385 名受试者中有 783 名（51/100000 人年）发生了 ILD。157 例（23.2%）死亡，272 例（10.4%）为对照组。ILD 与死亡风险显著相关（风险比 2.1，95%置信区间[CI]1.6-2.7），且在 40-59、60-69 和 70 岁及以上年龄组中更为明显。ILD 患者中有很大一部分死于呼吸系统疾病。