Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, 41931, Republic of Korea.
Department of Allergology, Hospital Serive of Kavaje, Kavaje, Albania.
BMC Pulm Med. 2018 Jun 4;18(1):96. doi: 10.1186/s12890-018-0660-2.
Understanding the risk factors that are associated with the development of interstitial lung disease might have an important role in understanding the pathogenetic mechanism of interstitial lung disease as well as prevention. We aimed to determine independent risk factors of interstitial lung disease development.
This was a retrospective cohort study with nationwide population-based 9-year longitudinal data. We selected subjects who were aged > 40 years at cohort entry and with a self-reported history of cigarette smoking. Cases were selected based on International Classification of Diseases codes. A cohort of 312,519 subjects were followed until December 2013. We used Cox regression analysis to calculate the hazard ratios (HRs) for interstitial lung disease development.
Interstitial lung disease developed in 1972 of the 312,519 subjects during the 9-year period. Smoking (HR: 1.2; 95% confidence interval [CI]: 1.1-1.4), hepatitis C (HR: 1.6; 95% CI: 1.1-2.3), history of tuberculosis (HR: 1.5; 95% CI: 1.1-1.9), history of pneumonia (HR: 1.6; 95% CI: 1.3-2.0), and chronic obstructive pulmonary disease (HR: 1.8; 95% CI: 1.6-2.1), men (HR: 1.9; 95% CI: 1.7-2.1) were significantly associated with the development of interstitial lung disease. The risk of interstitial lung disease development increases with age, and the risk was 6.9 times higher (95% CI: 5.9-8.0) in those aged over 70 than in their forties.
Smoking, hepatitis C, history of tuberculosis, history of pneumonia, chronic obstructive pulmonary disease, male sex, and older age were significantly associated with interstitial lung disease development.
了解与间质性肺疾病发展相关的危险因素，对于理解间质性肺疾病的发病机制以及预防可能具有重要作用。我们旨在确定间质性肺疾病发展的独立危险因素。
这是一项基于全国人口的 9 年纵向研究的回顾性队列研究。我们选择了在队列入组时年龄>40 岁且有吸烟史的患者作为研究对象。病例是根据国际疾病分类代码选择的。共有 312519 名受试者接受了随访，随访至 2013 年 12 月。我们使用 Cox 回归分析计算了间质性肺疾病发展的风险比（HR）。
在 9 年的时间里，312519 名受试者中有 1972 名发生了间质性肺疾病。吸烟（HR：1.2；95%置信区间[CI]：1.1-1.4）、丙型肝炎（HR：1.6；95% CI：1.1-2.3）、结核病史（HR：1.5；95% CI：1.1-1.9）、肺炎史（HR：1.6；95% CI：1.3-2.0）和慢性阻塞性肺疾病（HR：1.8；95% CI：1.6-2.1）、男性（HR：1.9；95% CI：1.7-2.1）与间质性肺疾病的发展显著相关。间质性肺疾病的发病风险随年龄增长而增加，70 岁以上人群的发病风险是 40 岁人群的 6.9 倍（95% CI：5.9-8.0）。
吸烟、丙型肝炎、结核病史、肺炎史、慢性阻塞性肺疾病、男性和年龄较大与间质性肺疾病的发展显著相关。
