Cushing Andrew C, Ramsay Edward C, Steeil James, Cox Sherry
J Zoo Wildl Med. 2017 Dec;48(4):1188-1192. doi: 10.1638/2017-0083.1.
A single 8 mg/kg dose of Cefovecin (Convenia®) was administered intramuscularly in the hindlimb of eight anesthetized captive tigers ( Panthera tigris) and serial blood samples were collected over the next 56 days to determine pharmacokinetic characteristics. High-performance liquid chromatography was utilized to determine plasma levels, and demonstrated a mean terminal half-life of 227.8 ± 29.3 hr. Cefovecin, >1 μg/ml, was detected in plasma levels up to 56 days postinjection. Protein binding of tiger plasma for cefovecin was 98%. The long duration of therapeutic plasma concentrations and lack of adverse effects make cefovecin a useful antimicrobial drug for tigers.
对八只麻醉后的圈养老虎（ Panthera tigris）后肢进行肌肉注射单剂量8mg/kg的头孢维星（Convenia®），并在接下来的56天内采集系列血样以确定药代动力学特征。采用高效液相色谱法测定血浆水平，结果显示平均终末半衰期为227.8±29.3小时。在注射后长达56天的血浆水平中均检测到头孢维星，其浓度>1μg/ml。头孢维星在老虎血浆中的蛋白结合率为98%。治疗性血浆浓度持续时间长且无不良反应，使得头孢维星成为对老虎有用的抗菌药物。
