雄性斯普拉格-道利大鼠旋转血栓弹力图的参考范围
Reference ranges for rotational thromboelastometry in male Sprague Dawley rats.
作者信息
Cruz Mariana Vigiola, Luker Jenna N, Carney Bonnie C, Brummel-Ziedins Kathleen E, Bravo Maria-Cristina, Orfeo Thomas, Chen Jason H, Moffatt Lauren T, Shupp Jeffrey W
机构信息
Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, DC USA.
The Burn Center, MedStar Washington Hospital Center, Washington, DC USA.
出版信息
Thromb J. 2017 Dec 28;15:31. doi: 10.1186/s12959-017-0154-0. eCollection 2017.
BACKGROUND
A functional coagulation assay was used to investigate the extrinsic pathway of coagulation on citrated whole blood samples from healthy adult male Sprague Dawley rats using the mini cup and pin system.
METHODS
Reference values for coagulation parameters from forty-three animals were calculated using data obtained from the ROTEM® hemostasis analyzer with the EXTEM test.
RESULTS
The following ranges, presented as the 2.5-97.5 percentiles, were established: CT [18-77], CFT [20-80], α [73-86], MCF [53-70], and ML [1-22], along with others.
CONCLUSIONS
These reference ranges can be used in future studies in rats to identify clinically significant coagulopathies.
背景
采用微型杯和针系统，运用功能性凝血试验，对来自健康成年雄性斯普拉格-道利大鼠的枸橼酸盐全血样本的凝血外源性途径进行研究。
方法
使用来自ROTEM®止血分析仪的EXTEM检测数据，计算43只动物凝血参数的参考值。
结果
确定了以下范围，以第2.5至97.5百分位数表示：CT[18 - 77]，CFT[20 - 80]，α[73 - 86]，MCF[53 - 70]，以及ML[1 - 22]，还有其他参数。
结论
这些参考范围可用于未来大鼠研究中，以识别具有临床意义的凝血病。
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