Walsh Mark, Fritz Stephanie, Hake Daniel, Son Michael, Greve Sarah, Jbara Manar, Chitta Swetha, Fritz Braxton, Miller Adam, Bader Mary K, McCollester Jonathon, Binz Sophia, Liew-Spilger Alyson, Thomas Scott, Crepinsek Anton, Shariff Faisal, Ploplis Victoria, Castellino Francis J
Memorial Hospital of South Bend, South Bend, Indiana 46601, USA.
Curr Drug Targets. 2016;17(8):954-70. doi: 10.2174/1389450117666160310153211.
Trauma-induced coagulopathy (TIC) is a recently described condition which traditionally has been diagnosed by the common coagulation tests (CCTs) such as prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (aPTT), platelet count, and fibrinogen levels. The varying sensitivity and specificity of these CCTs have led trauma coagulation researchers and clinicians to use Viscoelastic Tests (VET) such as Thromboelastography (TEG) to provide Targeted Thromboelastographic Hemostatic and Adjunctive Therapy (TTHAT) in a goal directed fashion to those trauma patients in need of hemostatic resuscitation. This review describes the utility of VETs, in particular, TEG, to provide TTHAT in trauma and acquired non-trauma-induced coagulopathy.
创伤性凝血病（TIC）是一种最近才被描述的病症，传统上通过常见的凝血试验（CCT）进行诊断，如凝血酶原时间/国际标准化比值（PT/INR）、活化部分凝血活酶时间（aPTT）、血小板计数和纤维蛋白原水平。这些CCT的敏感性和特异性各不相同，这使得创伤凝血研究人员和临床医生使用粘弹性试验（VET），如血栓弹力图（TEG），以目标导向的方式为那些需要止血复苏的创伤患者提供靶向血栓弹力图止血和辅助治疗（TTHAT）。本综述描述了VET，特别是TEG，在创伤和获得性非创伤性凝血病中提供TTHAT的效用。
