Bennett M H, Wainwright A P
London Hospital, Whitechapel.
Anaesthesia. 1989 Jan;44(1):28-30. doi: 10.1111/j.1365-2044.1989.tb11093.x.
Thyroid crisis on induction of anaesthesia was treated with dantrolene, because of a mistaken diagnosis of malignant hyperthermia. There was immediate improvement after dantrolene with reduction in muscle rigidity, mental confusion and pyrexia. High circulating T4 has an effect on calcium flux across the sarcoplasmic reticulum and dantrolene may inhibit this pathological mechanism. We suggest the same dosage regimen as is used in the treatment of malignant hyperthermia.
由于误诊为恶性高热，在麻醉诱导时发生的甲状腺危象用丹曲林进行了治疗。使用丹曲林后，肌肉僵硬、精神错乱和发热立即改善。高循环甲状腺素（T4）对钙通过肌浆网的通量有影响，丹曲林可能抑制这种病理机制。我们建议采用与治疗恶性高热相同的给药方案。
