Shen Jia, Spruck Charles
Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, San Diego, California, USA.
Oncotarget. 2017 Nov 16;8(66):110650-110655. doi: 10.18632/oncotarget.22469. eCollection 2017 Dec 15.
Epigenetic abnormalities are now realized as important as genetic alterations in contributing to the initiation and progression of cancer. Recent advancements in the cancer epigenetics field have identified extensive alterations of the epigenetic network in human cancers, including histone modifications and DNA methylation. F-box proteins, the substrate receptors of SCF (SKP1-Cullin1-F-box protein) E3 ubiquitin ligases, can directly and indirectly affect the balance of epigenetic regulation. In this brief review, we discuss our current understanding of F-box proteins in cellular epigenetic regulation and how dysregulation of these processes contribute to cancer development.
表观遗传异常现已被认为在癌症的发生和发展过程中与基因改变同样重要。癌症表观遗传学领域的最新进展已确定人类癌症中表观遗传网络存在广泛改变，包括组蛋白修饰和DNA甲基化。F-box蛋白是SCF（SKP1 - Cullin1 - F-box蛋白）E3泛素连接酶的底物受体，可直接或间接影响表观遗传调控的平衡。在这篇简短的综述中，我们讨论了目前对F-box蛋白在细胞表观遗传调控中的理解，以及这些过程的失调如何促进癌症发展。
