Assem E S, Symons I E
Department of Pharmacology, University College London.
Anaesthesia. 1989 Feb;44(2):121-4. doi: 10.1111/j.1365-2044.1989.tb11159.x.
In 1973 a 7-year-old girl had anaphylactic reactions after two general anaesthetics. In-vitro testing with the leucocyte challenge histamine release test showed a strong response to suxamethonium, and other tests indirectly suggested an allergic mechanism. The conclusion was that this was an allergy to suxamethonium. Further blood was sent for testing against a range of neuromuscular blockers, but the patient was 'lost' until she re-appeared 14 years later as an antenatal patient. In-vitro testing was repeated against suxamethonium and all the available neuromuscular blockers after delivery. The radio-allergosorbent test for allergen-specific IgE antibodies was performed on newly collected serum and that which had been stored for 13-14 years. Skin testing was also performed. The results remain positive and suggest a degree of allergy to all the neuromuscular blockers with the possible exception of vecuronium. The radio-allergosorbent test was negative in the patient's baby.
1973年，一名7岁女孩在接受两次全身麻醉后出现过敏反应。白细胞激发组胺释放试验的体外检测显示，对琥珀胆碱有强烈反应，其他检测间接提示存在过敏机制。结论是这是对琥珀胆碱的过敏反应。进一步采集血液针对一系列神经肌肉阻滞剂进行检测，但该患者“失联”了，直到14年后她作为一名产前患者再次出现。分娩后，再次针对琥珀胆碱和所有可用的神经肌肉阻滞剂进行体外检测。对新采集的血清以及储存了13 - 14年的血清进行了过敏原特异性IgE抗体的放射变应原吸附试验。还进行了皮肤试验。结果仍然呈阳性，提示对所有神经肌肉阻滞剂存在一定程度的过敏，维库溴铵可能除外。该患者婴儿的放射变应原吸附试验结果为阴性。
