Raiss Hanan, El Amarti Lamiae, Tigaud Jean Dominique, Layachi Mohamed, Bruyas Amandine, Boutayeb Saber, Errihani Hassan
Service d'Oncologie Médicale, Institut National d'Oncologie, CHU Rabat and Université Mohamed V, Rabat, Morocco.
Institut de Cancérologie, Hospices Civils de Lyon and Université de Lyon, Lyon, France.
J Gastrointest Oncol. 2017 Dec;8(6):E80-E83. doi: 10.21037/jgo.2017.08.06.
Acute pancreatitis is an inflammatory disorder of the pancreas characterized by upper abdominal pain, nausea, and vomiting, with elevated serum amylase or lipase. Gallstones and alcohol are the two main etiologies; drug-induced pancreatitis is uncommon. Paclitaxel associated with pancreatitis is very rare and since that time, only seven case reports have been published. We report a case of a 54-year-old female who developed an acute pancreatitis after administration of the first cycle of neoadjuvant chemotherapy with paclitaxel (175 mg/m over 3 h) and carboplatin (AUC 6) for ovarian adenocarcinoma. After conservative management, pancreatitis was resolved. The patient received an additional five cycles of carboplatin with no complication. Because Paclitaxel is used in many chemotherapy protocols, it is important for clinicians to be aware that paclitaxel can induce acute pancreatitis, as early diagnosis can be vital.
急性胰腺炎是一种胰腺的炎症性疾病，其特征为上腹部疼痛、恶心和呕吐，伴有血清淀粉酶或脂肪酶升高。胆结石和酒精是两个主要病因；药物性胰腺炎并不常见。与胰腺炎相关的紫杉醇非常罕见，自那时以来，仅发表了7例病例报告。我们报告一例54岁女性，在接受用于卵巢腺癌的新辅助化疗第一周期（紫杉醇175mg/m²，静脉滴注3小时，卡铂AUC 6）后发生急性胰腺炎。经过保守治疗，胰腺炎得到缓解。该患者又接受了五个周期的卡铂治疗，无并发症发生。由于紫杉醇用于多种化疗方案，临床医生应意识到紫杉醇可诱发急性胰腺炎，因为早期诊断至关重要。
