Copenhagen Neuromuscular Center Department of Neurology Rigshospitalet University of Copenhagen Copenhagen Denmark.
Brain Behav. 2017 Nov 2;7(12):e00794. doi: 10.1002/brb3.794. eCollection 2017 Dec.
Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy associated with impaired walking capacity. Some patients are too weak in the lower extremity muscles to walk at gravity with sufficient intensity or duration to gain benefit.
The aim was to investigate the effect of aerobic anti-gravity exercise in weak patients with CMT 1A and X.
Five adult patients performed moderate-intensity aerobic anti-gravity exercise 3/week for 10 weeks.
There was a significant positive difference in Berg balance scale and postural stability test between test occasions, and walking distance in the 6-min walk test trended to increase.
The study indicates that the anti-gravity treadmill training of patients with CMT should be pursued in larger CMT cohorts.
Charcot-Marie-Tooth（CMT）病是一种遗传性周围神经病，与行走能力受损有关。一些患者下肢肌肉过于虚弱，无法以足够的强度或持续时间在重力作用下行走，从而获益。
本研究旨在探讨有氧抗重力运动对 CMT1A 和 X 型弱型患者的影响。
5 名成年患者每周进行 3 次中等强度的有氧抗重力运动，持续 10 周。
Berg 平衡量表和姿势稳定测试在测试时出现显著的正差异，6 分钟步行测试的步行距离呈上升趋势。
该研究表明，CMT 患者的抗重力跑步机训练应在更大的 CMT 队列中进行。
