Wright N C, Kilmer D D, McCrory M A, Aitkens S G, Holcomb B J, Bernauer E M
Department of Physical Medicine and Rehabilitation, University of California, Davis 95616, USA.
Arch Phys Med Rehabil. 1996 Jan;77(1):64-9. doi: 10.1016/s0003-9993(96)90222-1.
Poor cardiorespiratory endurance is a common finding in neuromuscular disease (NMD), and the capacity of such patients to respond to aerobic training is unclear. This study was conducted to determine if a 12-week walking program results in increased aerobic capacity in slowly progressive NMD subjects, whether such a program is safely tolerated, and whether such patients can adhere to a self-monitored, home-based training program.
Before-after trial.
Subjects' homes.
A cohort of 8 slowly progressive NMD subjects (4 men, 4 women) followed in the neuromuscular disease clinic participated (age, 36.6 +/- 8.0 yrs; ht, 170 +/- 11 cm; wt, 74.3 +/- 19.0 kg) (Mean +/- SD).
Subjects walked 15 to 30 min 3 to 4 days a week at 50% to 60% of their heart rate reserve.
Resting, submaximal, and peak heart rates, systolic and diastolic blood pressures, oxygen uptake, and peak power output.
Graded exercise testing to volitional fatigue using a semirecumbent cycle ergometer before and after the training program found significant decreases in submaximal heart rate by 7 +/- 3 beats/min (Mean +/- SEM) (95% CI = -23 to 9) (p = .046) and submaximal systolic blood pressure by 11 +/- 4 mmHg (95% CI = -31 to 9) (p = .019), and nonsignificant increases in peak power output and VO2.
These results suggest that moderate-intensity aerobic exercise training is well tolerated and may provide modest improvement in aerobic capacity in slowly progressive NMD subjects.
心肺耐力差是神经肌肉疾病（NMD）的常见表现，此类患者对有氧运动训练的反应能力尚不清楚。本研究旨在确定一项为期12周的步行计划是否能提高缓慢进展型NMD患者的有氧运动能力，该计划是否能被安全耐受，以及此类患者能否坚持自我监测的居家训练计划。
前后对照试验。
受试者家中。
8名在神经肌肉疾病诊所随访的缓慢进展型NMD受试者（4名男性，4名女性）参与研究（年龄36.6±8.0岁；身高170±11厘米；体重74.3±19.0千克）（均值±标准差）。
受试者每周3至4天，以心率储备的50%至60%进行15至30分钟的步行。
静息心率、次最大心率和峰值心率、收缩压和舒张压、摄氧量以及峰值功率输出。
在训练计划前后，使用半卧位自行车测力计进行递增运动试验至自愿疲劳，发现次最大心率显著降低7±3次/分钟（均值±标准误）（95%置信区间=-23至9）（p=0.046），次最大收缩压显著降低11±4毫米汞柱（95%置信区间=-31至9）（p=0.019），峰值功率输出和VO2有不显著增加。
这些结果表明，中等强度的有氧运动训练耐受性良好，可能会使缓慢进展型NMD患者的有氧运动能力有适度改善。
