Department of Epidemiology and Health Statistics, The College of Public Health of Qingdao University, 38 Dengzhou Road, Qingdao, 266021, Shandong, People's Republic of China.
Eur J Nutr. 2019 Feb;58(1):391-398. doi: 10.1007/s00394-017-1603-z. Epub 2018 Jan 3.
Early life exposure to famine may affect the susceptibility to metabolic disorders including dyslipidemia. However, few studies explored the association between them in Chinese population. We aimed to evaluate the association between Chinese famine (1959-1961) exposure during early life and the risk of dyslipidemia in adulthood.
The study performed a historic cohort study and data were from China Health and Nutrition Survey conducted in 2009. A total of 4843 subjects born between 1941 and 1966 were categorized into fetal-infant exposed group (N = 433), childhood exposed group (N = 2132), adolescence exposed group (N = 1140), and unexposed group (N = 1138), respectively. Dyslipidemia was defined by Chinese adult dyslipidemia prevention guide (2016 edition). We compared fetal exposed group, childhood exposed group, and adolescence exposed group to unexposed group using logistic regression models to assess the effect of famine exposure on later dyslipidemia.
The prevalence of dyslipidemia among subjects in unexposed group, fetal exposed group, childhood exposed group, and adolescence exposed group was 56.40, 64.00, 63.90, and 63.90%, respectively. Compared with unexposed group, participants exposed to famine in fetal period (OR 1.34, 95% CI 1.05-1.70), childhood (OR 1.44, 95% CI 1.23-1.69), and adolescence (OR 1.41, 95% CI 1.17-1.71) had higher risks of dyslipidemia in adults after adjustment for potential confounders.
Exposure to Chinese famine in early life was associated with increased risk of dyslipidemia in adulthood. Preventing undernutrition in early life is an appropriate recommendation to reduce the prevalence of later dyslipidemia.
生命早期暴露于饥荒可能会影响包括血脂异常在内的代谢紊乱的易感性。然而，很少有研究探讨中国人群中两者之间的关联。本研究旨在评估中国饥荒（1959-1961 年）暴露于生命早期与成年期血脂异常风险之间的关系。
本研究进行了一项历史性队列研究，数据来自 2009 年进行的中国健康与营养调查。共有 4843 名出生于 1941 年至 1966 年的受试者分为胎儿-婴儿暴露组（N=433）、儿童暴露组（N=2132）、青少年暴露组（N=1140）和未暴露组（N=1138）。血脂异常根据《中国成人血脂异常防治指南（2016 年版）》定义。我们使用逻辑回归模型将胎儿暴露组、儿童暴露组和青少年暴露组与未暴露组进行比较，以评估饥荒暴露对以后血脂异常的影响。
未暴露组、胎儿暴露组、儿童暴露组和青少年暴露组的血脂异常患病率分别为 56.40%、64.00%、63.90%和 63.90%。与未暴露组相比，胎儿期（OR 1.34，95%CI 1.05-1.70）、儿童期（OR 1.44，95%CI 1.23-1.69）和青少年期（OR 1.41，95%CI 1.17-1.71）暴露于饥荒的参与者成年后患血脂异常的风险更高，调整了潜在混杂因素后。
生命早期暴露于中国饥荒与成年后患血脂异常的风险增加有关。预防生命早期的营养不良是减少以后血脂异常患病率的适当建议。
