Kim Jong Wook, Bae Young Dae, Ahn Sun Tae, Kim Jin Wook, Kim Je Jong, Moon Du Geon
Department of Urology, Korea University College of Medicine, Seoul, Korea.
Institute of Regenerative Medicine, Korea University, Seoul, Korea.
World J Mens Health. 2018 Jan;36(1):73-78. doi: 10.5534/wjmh.17029.
In epidemiological studies, there are various associations of androgen receptor (AR) CAG with several diseases or phenotypes. However, the relationship between CAG repeat length and metabolic syndrome (MS) remains unclear, especially in Asian populations. This study was designed to evaluate the relationship between AR CAG repeat length polymorphism and MS in a Korean male population.
We explored the relationship between AR CAG repeat length polymorphism and MS in a Korean male population (n=337) from 2013 to 2014. AR CAG repeat were determined by microsatellite fragment sizing. Components of MS and laboratory data (lipid profile, fasting glucose, and glycated hemoglobin (HbA1c)) were analyzed with AR CAG repeat length.
The mean AR CAG repeat length was 22.3±4.7. Sixty-nine men (20.5%) were diagnosed with MS. Men with MS showed significantly longer AR CAG repeat lengths compared with men without MS (26.2 vs. 21.4, p<0.001). With increasing CAG repeat, the number of components meeting the NCEP criteria increased significantly. AR CAG repeat length was associated significantly with high density lipoprotein (HDL), triglyceride, and HbA1c levels. In the multivariate analysis, CAG repeat length, waist circumference, and levels of HDL were independently associated with MS. (odds ratio (OR)=1.37, 1.19 and 0.90, p<0.001, 0.045, and 0.001, respectively).
AR CAG repeat length was associated with MS and laboratory test results, such as those for HDL, triglycerides, and HbA1c, in Korean males. Longer CAG repeat length was identified as a risk factor for MS in Korean males.
在流行病学研究中，雄激素受体（AR）CAG与多种疾病或表型存在各种关联。然而，CAG重复长度与代谢综合征（MS）之间的关系仍不明确，尤其是在亚洲人群中。本研究旨在评估韩国男性人群中AR CAG重复长度多态性与MS之间的关系。
我们在2013年至2014年期间，对337名韩国男性人群探索了AR CAG重复长度多态性与MS之间的关系。通过微卫星片段大小测定来确定AR CAG重复。分析了MS的组成部分以及实验室数据（血脂谱、空腹血糖和糖化血红蛋白（HbA1c））与AR CAG重复长度的关系。
AR CAG重复长度的平均值为22.3±4.7。69名男性（20.5%）被诊断为MS。与未患MS的男性相比，患MS的男性AR CAG重复长度显著更长（26.2对21.4，p<0.001）。随着CAG重复次数增加，符合美国国家胆固醇教育计划（NCEP）标准的组成部分数量显著增加。AR CAG重复长度与高密度脂蛋白（HDL）、甘油三酯和HbA1c水平显著相关。在多变量分析中，CAG重复长度、腰围和HDL水平与MS独立相关。（比值比（OR）分别为1.37、1.19和0.90，p分别<0.001、0.045和0.001）。
在韩国男性中，AR CAG重复长度与MS以及HDL、甘油三酯和HbA1c等实验室检测结果相关。较长的CAG重复长度被确定为韩国男性患MS的一个风险因素。
