Svartberg J
Department of Medicine, University Hospital of North Norway, Tromsø, Norway.
Int J Impot Res. 2007 Mar-Apr;19(2):124-8. doi: 10.1038/sj.ijir.3901499. Epub 2006 Jul 20.
Low levels of testosterone, hypogonadism, have several common features with the metabolic syndrome. In the Tromsø Study, a population-based health survey, testosterone levels were inversely associated with anthropometrical measurements, and the lowest levels of total and free testosterone were found in men with the most pronounced central obesity. Total testosterone was inversely associated with systolic blood pressure, and men with hypertension had lower levels of both total and free testosterone. Furthermore, men with diabetes had lower testosterone levels compared to men without a history of diabetes, and an inverse association between testosterone levels and glycosylated hemoglobin was found. Thus, there are strong associations between low levels of testosterone and the different components of the metabolic syndrome. In addition, an independent association between low testosterone levels and the metabolic syndrome itself has recently been presented in both cross-sectional and prospective population-based studies. Thus, testosterone may have a protective role in the development of metabolic syndrome and subsequent diabetes mellitus and cardiovascular disease in aging men. However, clinical trials are needed to confirm this assumption.
低水平睾酮，即性腺功能减退，与代谢综合征有几个共同特征。在特罗姆瑟研究（一项基于人群的健康调查）中，睾酮水平与人体测量指标呈负相关，在中心性肥胖最明显的男性中发现总睾酮和游离睾酮水平最低。总睾酮与收缩压呈负相关，高血压男性的总睾酮和游离睾酮水平均较低。此外，与无糖尿病史的男性相比，糖尿病男性的睾酮水平较低，且发现睾酮水平与糖化血红蛋白之间呈负相关。因此，低水平睾酮与代谢综合征的不同组分之间存在密切关联。此外，最近在基于人群的横断面研究和前瞻性研究中均表明低睾酮水平与代谢综合征本身存在独立关联。因此，睾酮可能在老年男性代谢综合征及后续糖尿病和心血管疾病的发生发展中具有保护作用。然而，需要临床试验来证实这一假设。
