载脂蛋白相关指数与 2 型糖尿病患者体脂水平相关。
Atherogenic Index of Plasma is Associated with Body Fat Level in Type 2 Diabetes Mellitus Patients.
机构信息
Department of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.
Institute of Endocrinology and Metabolic Diseases, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.
出版信息
Curr Vasc Pharmacol. 2018;16(6):589-595. doi: 10.2174/1570161116666180103125456.
OBJECTIVE
To investigate the characteristics of body fat distribution and the relationship between body fat index and Atherogenic Index of Plasma (AIP) in Type 2 Diabetes Mellitus (T2DM) patients.
METHODS
A total of 316 participants were divided into a T2DM group and a non-diabetes group (controls). According to the Visceral Fat Area (VFA), all participants were further divided into VFA ≥100 cm2 and VFA <100 cm2 groups. To compare the differences of blood lipid, blood glucose, body fat index and AIP between the 2 groups, single factor correlation analysis was used to determine the correlation between the indexes and AIP, and multiple linear regression was used to analyse the correlation between the related factors and AIP.
RESULTS
The body fat index (including body fat content, Percentage of Body Fat (PBF), Waist to Hip Fat Ratio (WHR) and VFA), Triglyceride (TG), Fasting Insulin (FINS), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and AIP in T2DM group were significantly higher than in the control group, while High Density Lipoprotein Cholesterol (HDL-C) level was significantly higher in the control group. In the VFA≥100 cm2 group, TG, Low Density Lipoprotein Cholesterol (LDL-C), FINS, HOMAIR and AIP were all higher than that in the VFA <100 cm2 group. There was a positive correlation between AIP and VFA, body fat content, percentage of body fat, and WHR, respectively. There was also a negative correlation between AIP and HDL-C, which was not related to age, sex, Fasting Glucose (FPG), glycosylated haemoglobin (HbA1c), Total Cholesterol (TC), LDL-C and course of disease. Compared with the VFA <100 cm2 group, the VFA ≥100 cm2 group had higher blood Uric Acid (UA) levels and UA was positively correlated with VFA. After correcting the effect of UA on AIP, VFA was still an independent related factor of AIP, and VFA increased the risk of atherosclerosis by increased UA.
CONCLUSION
T2DM patients have the abnormal distribution of body fat and a high VFA, which was associated with AIP.
目的
探讨 2 型糖尿病（T2DM）患者体脂分布特征及体脂指数与血浆致动脉粥样硬化指数（AIP）的关系。
方法
将 316 例研究对象分为 T2DM 组和非糖尿病组（对照组）。根据内脏脂肪面积（VFA），将所有患者进一步分为 VFA≥100cm2 组和 VFA<100cm2 组。采用单因素方差分析比较两组间血脂、血糖、体脂指数及 AIP 的差异，采用单因素相关分析判断各指标与 AIP 的相关性，采用多元线性回归分析 AIP 的相关因素。
结果
T2DM 组体脂指数（包括体脂含量、体脂百分比、腰臀比、VFA）、三酰甘油（TG）、空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA-IR）及 AIP 均高于对照组，而高密度脂蛋白胆固醇（HDL-C）水平高于对照组。VFA≥100cm2 组的 TG、LDL-C、FINS、HOMA-IR 及 AIP 均高于 VFA<100cm2 组。AIP 与 VFA、体脂含量、体脂百分比、腰臀比均呈正相关，与 HDL-C 呈负相关，与年龄、性别、空腹血糖（FPG）、糖化血红蛋白（HbA1c）、总胆固醇（TC）、LDL-C 及病程均无相关性。与 VFA<100cm2 组相比，VFA≥100cm2 组血尿酸（UA）水平较高，UA 与 VFA 呈正相关。校正 UA 对 AIP 的影响后，VFA 仍是 AIP 的独立相关因素，且 VFA 通过增加 UA 增加了动脉粥样硬化的风险。
结论
T2DM 患者体脂分布异常，VFA 升高，与 AIP 相关。
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