Lorenzo M Donini, MD, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy, phone: +39 06 4969 0216, fax: +39 06 4991 0699, email:
J Nutr Health Aging. 2018;22(1):44-52. doi: 10.1007/s12603-017-0919-y.
Malnutrition is a frequent condition in the elderly especially in hospitals and in nursing homes, and even among the free-living elders the prevalence is not negligible (5-10%). Awareness towards malnutrition is still limited. The lack of time for nutritional assessment by the overcommitted healthcare personnel, including the general practitioners (GPs), may represent one possible explanation for limited recognition of malnutrition. Therefore, a self-administered instrument could be useful in raising alert on the GPs and allow early detection of malnutrition and early care provision. The aim of the present study was to analyze the validity of the Self-MNA that takes cue from the Mini Nutritional Assessment- Short Form (MNA-SF) and has been adapted to be self-administered by free-living elderly subjects.
Participants were recruited from patients referring to the GP offices in Italy. Nutritional evaluation was performed through the administration of Full-MNA, MNA-SF and Self-MNA. The comorbidity level was assessed through the Cumulative Illness Rating Scale (CIRS). The level of difficulty in filling out the test was reported by the participants, and the time spent to complete the Self-MNA was also registered.
A total of 226 subjects, 125 women and 101 men (75.1 ±8 and 75.3 ± 8 years old, respectively; p=0.89) were enrolled, and 214 (94.7%) of them completed the Self-MNA. According with the Full-MNA test score, 8.4% of women and 3.5% of men were classified as malnourished, whereas 32.7% of women and 31.4% of men were at risk of malnutrition. Agreement between Self-MNA and Full-MNA, and Self-MNA vs. MNA-SF was classified as "moderate" (k = 0.476 and 0.496 respectively; p < 0.001). Self-MNA showed a fair predictive value compared to the Full-MNA and MNA-SF tests (76.6 and 79.9%, respectively) with a barely adequate sensitivity (70.9 and 75.4%, respectively). The analysis of the characteristics of FN (false negative: subjects who were considered at risk of malnutrition or malnourished at Full-MNA but not at Self-MNA) showed that the clinical and functional aspects of these subjects (age, comorbidity and severity, time necessary to complete the Self-MNA, decrease in food intake, severe illness in the past 3 months, dementia and depression, fluid intake, need for feeding assistance, arm and calf circumferences) were very similar to the characteristics of true positive subjects. Patients required 6.7 ± 4.5 minutes to complete the test and 25 subjects (11.7%) needed more than 10 minutes, up to a maximum of 30 minutes. Patients who stated a greater difficulty were older (79.8 ± 7 vs. 73.5 ± 7 years; p<0.001), they were more «malnourished» at Full-MNA (10.7 vs. 1,7%; p= 0.006) and clinical status was characterized by a higher severity index (1.72 ± 0.6 vs. 1.41 ± 0.4; p= 0.008).
In the present study we investigated the validity of the Self-MNA in a sample of free-living elderly subjects. The results obtained confirm the validity of the test that may represent a useful tool for the GPs, although some important limitations need to be considered, limiting its use in clinical practice.
营养不良是老年人,尤其是医院和养老院中老年人的常见病症,即使在自由生活的老年人中,其患病率也不容忽视(5-10%)。人们对营养不良的认识仍然有限。负责医疗的医护人员,包括全科医生(GP),由于时间紧迫,可能无法进行营养评估,这可能是营养不良未被充分认识的原因之一。因此,自我管理的工具可能有助于提高全科医生的警惕性,从而更早地发现营养不良并提供早期护理。本研究的目的是分析源自 Mini Nutritional Assessment-Short Form(MNA-SF)的自我 MNA 的有效性,该工具已被改编为可供自由生活的老年受试者自我管理。
参与者从意大利的全科医生办公室的患者中招募。通过Full-MNA、MNA-SF 和 Self-MNA 对营养状况进行评估。通过 Cumulative Illness Rating Scale(CIRS)评估合并症的严重程度。参与者报告填写测试的难度,同时还记录完成 Self-MNA 所需的时间。
共招募了 226 名受试者,其中 125 名女性和 101 名男性(分别为 75.1 ± 8 和 75.3 ± 8 岁;p=0.89),其中 214 名(94.7%)完成了 Self-MNA。根据 Full-MNA 测试评分,8.4%的女性和 3.5%的男性被归类为营养不良,而 32.7%的女性和 31.4%的男性存在营养不良风险。Self-MNA 与 Full-MNA 和 Self-MNA 与 MNA-SF 的一致性被归类为“中度”(k 值分别为 0.476 和 0.496;p < 0.001)。Self-MNA 与 Full-MNA 和 MNA-SF 测试相比具有相当的预测价值(分别为 76.6%和 79.9%),但敏感性较低(分别为 70.9%和 75.4%)。对 FN(假阴性:在 Full-MNA 中被认为存在营养不良或营养风险但不在 Self-MNA 中的受试者)特征的分析表明,这些受试者的临床和功能方面(年龄、合并症和严重程度、完成 Self-MNA 所需的时间、食物摄入量减少、过去 3 个月内的严重疾病、痴呆和抑郁症、液体摄入、需要喂食帮助、手臂和小腿周长)与真阳性受试者的特征非常相似。患者完成测试需要 6.7 ± 4.5 分钟,25 名患者(11.7%)需要超过 10 分钟,最多需要 30 分钟。报告难度较大的患者年龄较大(79.8 ± 7 岁 vs. 73.5 ± 7 岁;p<0.001),在 Full-MNA 中营养状况更差(10.7% vs. 1%;p=0.006),临床状况的严重程度指数更高(1.72 ± 0.6 vs. 1.41 ± 0.4;p=0.008)。
在本研究中,我们在自由生活的老年受试者样本中研究了 Self-MNA 的有效性。结果证实了该测试的有效性,它可能是全科医生的有用工具,尽管需要考虑一些重要的限制,限制了其在临床实践中的应用。