Veronese Nicola, Vassallo Giusy, Armata Maria, Cilona Laura, Casalicchio Salvatore, Masnata Roberta, Costantino Claudio, Vitale Francesco, Giammanco Giovanni Maurizio, Maggi Stefania, Sabico Shaun, Al-Daghri Nasser M, Dominguez Ligia J, Barbagallo Mario
Geriatric Unit, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, 90127 Palermo, Italy.
Hygiene Section, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, 90127 Palermo, Italy.
Vaccines (Basel). 2022 Apr 3;10(4):555. doi: 10.3390/vaccines10040555.
It is known that influenza, herpes zoster, pneumococcal and pertussis infections may increase morbidity and mortality in older people. Vaccinations against these pathogens are effective in older adults. Frailty seems to be an important determinant of vaccination rates, yet data supporting this association are still missing. Therefore, we aimed to investigate the prevalence of four recommended vaccinations (influenza, herpes zoster, pneumococcal and diphtheria-tetanus-pertussis) and the association with multidimensional frailty assessed using a self-reported comprehensive geriatric assessment tool, i.e., the multidimensional prognostic index (SELFY-MPI). Older participants visiting the outpatient clinic of Azienda Ospedaliera Universitaria, Palermo, Italy were included. The SELFY-MPI questionnaire score was calculated based on eight different domains, while the vaccination status was determined using self-reported information. We included 319 participants from the 500 initially considered (63.8%). Vaccination against influenza was observed in 70.5% of the cases, whilst only 1.3% received the vaccination against diphtheria-tetanus-pertussis. Participants with higher SELFY-MPI scores were more likely to report vaccination against pneumococcus (45.6 vs. 28.3%, = 0.01), whilst no significant differences were observed for the other vaccinations. In conclusion, the coverage of recommended vaccinations is low. Higher SELFY-MPI scores and vaccination status, particularly anti-pneumococcus, appear to be associated, but future studies are urgently needed for confirming that frailty is associated with vaccination status in older people.
众所周知，流感、带状疱疹、肺炎球菌和百日咳感染可能会增加老年人的发病率和死亡率。针对这些病原体的疫苗接种对老年人有效。虚弱似乎是疫苗接种率的一个重要决定因素，但支持这种关联的数据仍然缺失。因此，我们旨在调查四种推荐疫苗（流感、带状疱疹、肺炎球菌和白喉-破伤风-百日咳疫苗）的接种率，以及使用自我报告的综合老年评估工具即多维预后指数（SELFY-MPI）评估的多维虚弱之间的关联。纳入了在意大利巴勒莫大学医院门诊就诊的老年参与者。SELFY-MPI问卷得分基于八个不同领域计算得出，而疫苗接种状况则通过自我报告的信息确定。我们从最初考虑的500名参与者中纳入了319名（63.8%）。70.5%的病例接种了流感疫苗，而只有1.3%的人接种了白喉-破伤风-百日咳疫苗。SELFY-MPI得分较高的参与者更有可能报告接种了肺炎球菌疫苗（45.6%对28.3%，P = 0.01），而其他疫苗接种情况未观察到显著差异。总之，推荐疫苗的接种覆盖率较低。较高的SELFY-MPI得分与疫苗接种状况，特别是抗肺炎球菌疫苗接种状况似乎有关联，但迫切需要未来的研究来证实虚弱与老年人的疫苗接种状况有关。
