上丘在决策标准中的作用。
A Role for the Superior Colliculus in Decision Criteria.
机构信息
Fuster Laboratory of Cognitive Neuroscience, UCLA, Los Angeles, CA 90095, USA; Departments of Psychiatry and Biobehavioral Sciences and Neurobiology, UCLA, Los Angeles, CA 90095, USA; Semel Institute of Neuroscience and Human Behavior , UCLA, Los Angeles, CA 90095, USA; Brain Research Institute , UCLA, Los Angeles, CA 90095, USA; David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
Department of Psychology, UCLA, Los Angeles, CA 90095, USA.
出版信息
Neuron. 2018 Jan 3;97(1):181-194.e6. doi: 10.1016/j.neuron.2017.12.006.
Simple decisions arise from the evaluation of sensory evidence. But decisions are determined by more than just evidence. Individuals establish internal decision criteria that influence how they respond. Where or how decision criteria are established in the brain remains poorly understood. Here, we show that neuronal activity in the superior colliculus (SC) predicts changes in decision criteria. Using a novel "Yes-No" task that isolates changes in decision criterion from changes in decision sensitivity, and computing neuronal measures of sensitivity and criterion, we find that SC neuronal activity correlates with the decision criterion regardless of the location of the choice report. We also show that electrical manipulation of activity within the SC produces changes in decisions consistent with changes in decision criteria and are largely independent of the choice report location. Our correlational and causal results together provide strong evidence that SC activity signals the position of a decision criterion. VIDEO ABSTRACT.
简单决策源于对感官证据的评估。但决策不仅仅取决于证据。个体建立内部决策标准，影响他们的反应方式。决策标准在大脑中是如何建立的还知之甚少。在这里，我们表明，上丘（SC）中的神经元活动可以预测决策标准的变化。使用一种新颖的“是-否”任务，该任务可以将决策标准的变化与决策敏感性的变化分离开来，并计算神经元的敏感性和标准测量值，我们发现，无论选择报告的位置如何，SC 神经元活动都与决策标准相关。我们还表明，对 SC 内活动的电操作会产生与决策标准变化一致的决策变化，并且在很大程度上独立于选择报告的位置。我们的相关和因果结果共同提供了强有力的证据，表明 SC 活动信号代表了决策标准的位置。视频摘要。
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