VIB-KU Leuven Center for Brain and Disease Research, 3000 Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, 3000 Leuven, Belgium.
VIB-KU Leuven Center for Brain and Disease Research, 3000 Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, 3000 Leuven, Belgium.
Neuron. 2018 Jan 3;97(1):3-4. doi: 10.1016/j.neuron.2017.12.024.
α-Synuclein resides in Lewy bodies in Parkinson's disease. Ordonez et al. (2017) now show that α-syn disrupts the actin network, causing Drp1-dependent mitochondrial fission defects. This is similar to defects induced by the PD risk factor Tau, suggesting converging pathways in neurodegeneration.
α-突触核蛋白存在于帕金森病的路易体中。Ordonez 等人（2017 年）现在表明，α-突触核蛋白破坏了肌动蛋白网络，导致依赖 Drp1 的线粒体裂变缺陷。这与帕金森病风险因素 Tau 诱导的缺陷相似，表明神经退行性变过程中存在趋同途径。
