收养儿童的过敏易感性：“Bambino Gesù 儿童医院”的横断面研究。

Susceptibility to allergy in adoptive children: a cross-sectional study at "Bambino Gesù Children's Hospital".

机构信息

Division of Immunology and Infectious Diseases, University-Hospital Pediatric Department (DPUO), Bambino Gesù Children Hospital, Piazza Sant'Onofrio 4, 00165, Rome, Italy.

Epidemiology Unit, Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

出版信息

Ital J Pediatr. 2018 Jan 4;44(1):3. doi: 10.1186/s13052-017-0440-2.

DOI:10.1186/s13052-017-0440-2

PMID:29301554

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5755410/

Abstract

BACKGROUND

Prevalence of allergy has steeply increased during the past few decades, particularly in high-income countries. The development of atopy could present different characteristics in internationally adopted children with regard to incidence, specific patterns of allergies and timing of occurrence. We aimed to investigate the occurrence of allergic diseases among adopted children in Italy.

METHODS

We collected demographic information, preadoption immunization data, infectious diseases screening results, immunological status, and performed hematological and biochemical tests according to a standardized protocol in 108 adopted children.

RESULTS

At initial visit (mean age was 5.7 ± 3.2 years), 48 children displayed elevated total serum IgE levels with a prevalence of 56.5% (95%CI: 0.45; 0.67). The prevalences of children screened positive for one or more food allergens and inhalants were 30.1% (95%CI: 19.9%; 42.0%) and 34.3% (95%CI: 23.3%; 46.6%) respectively, only 9 children exhibited abnormal absolute eosinophil counts, 23 (21.3%) had a parasitic infection and 60 (55.6%) had received at least one dose of vaccine.

CONCLUSIONS

Children without medical records or with a past medical history suggestive of atopy should perform a thorough allergy evaluation at the time of adoption. Our study offers also a glimpse at the vaccination status and immune-allergic profiles of recent migrant children in Italy.

摘要

背景

在过去几十年中，过敏的患病率急剧上升，尤其是在高收入国家。特应性的发展在国际收养儿童中可能表现出不同的特征，包括发病率、过敏的具体模式和发生时间。我们旨在研究意大利收养儿童中过敏性疾病的发生情况。

方法

我们收集了 108 名收养儿童的人口统计学信息、领养前免疫接种数据、传染病筛查结果、免疫状态，并根据标准化方案进行了血液学和生化检查。

结果

在初次就诊时（平均年龄为 5.7±3.2 岁），48 名儿童的总血清 IgE 水平升高，患病率为 56.5%（95%CI：0.45；0.67）。筛查出一种或多种食物过敏原和吸入性过敏原阳性的儿童患病率分别为 30.1%（95%CI：19.9%；42.0%）和 34.3%（95%CI：23.3%；46.6%），仅有 9 名儿童的绝对嗜酸性粒细胞计数异常，23 名（21.3%）患有寄生虫感染，60 名（55.6%）至少接种过一剂疫苗。