Research Unit Women's and Children's Health, The Juliane Marie Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Research Unit of Gynecology and Obstetrics, Institute of Clinical Research, University of Southern Denmark, Odense, and Odense University Hospital.
J Am Acad Child Adolesc Psychiatry. 2018 Jan;57(1):28-32.e1. doi: 10.1016/j.jaac.2017.10.002. Epub 2017 Oct 9.
Maternal rheumatoid arthritis (RA) has been associated with an increased risk of autism spectrum disorder (ASD) in the offspring. We assessed the potential influence of both maternal and paternal RA on the risk of ASD in offspring to disentangle the influence of genetic inheritance from other conditions potentially leading to fetal programming.
The nationwide cohort study included all children born alive from 1977 to 2008 in Denmark (N = 1,917,723). Cox regression models were used to calculate hazard rate ratios (HR) of ASD in offspring exposed to maternal or paternal RA, compared to unexposed children.
Maternal RA was associated with an approximately 30% increased risk of ASD in the offspring (HR = 1.31 and 95% CI = 1.06-1.63). Also, paternal RA seemed to increase the risk of ASD by approximately 30% (HR = 1.33, 95% CI = 0.97-1.82).
Our findings suggest maternal as well as paternal RA to be associated with an increased risk of ASD in the offspring, indicating that genetic factors associated with RA may also play a role in the etiology of ASD in children of parents with RA.
母体类风湿关节炎（RA）与后代自闭症谱系障碍（ASD）的风险增加有关。我们评估了母体和父体 RA 对后代 ASD 风险的潜在影响，以厘清遗传易感性与其他可能导致胎儿编程的条件的影响。
这项全国性队列研究纳入了 1977 年至 2008 年期间在丹麦出生的所有活产儿（N=1,917,723）。使用 Cox 回归模型计算了暴露于母体或父体 RA 的后代患 ASD 的风险比（HR），并与未暴露于 RA 的儿童进行比较。
母体 RA 使后代患 ASD 的风险增加了约 30%（HR=1.31，95%CI=1.06-1.63）。此外，父体 RA 似乎也使后代患 ASD 的风险增加了约 30%（HR=1.33，95%CI=0.97-1.82）。
我们的研究结果表明母体和父体 RA 均与后代 ASD 风险增加相关，表明与 RA 相关的遗传因素也可能在 RA 父母的子女中 ASD 的发病机制中发挥作用。
