Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Avon and Wiltshire Partnership NHS Mental Health Trust, Bath, UK.
Nat Med. 2022 Jul;28(7):1406-1411. doi: 10.1038/s41591-022-01845-9. Epub 2022 Jun 2.
Evidence linking parental inflammatory bowel disease (IBD) with autism in children is inconclusive. We conducted four complementary studies to investigate associations between parental IBD and autism in children, and elucidated their underlying etiology. Conducting a nationwide population-based cohort study using Swedish registers, we found evidence of associations between parental diagnoses of IBD and autism in children. Polygenic risk score analyses of the Avon Longitudinal Study of Parents and Children suggested associations between maternal genetic liability to IBD and autistic traits in children. Two-sample Mendelian randomization analyses provided evidence of a potential causal effect of genetic liability to IBD, especially ulcerative colitis, on autism. Linkage disequilibrium score regression did not indicate a genetic correlation between IBD and autism. Triangulating evidence from these four complementary approaches, we found evidence of a potential causal link between parental, particularly maternal, IBD and autism in children. Perinatal immune dysregulation, micronutrient malabsorption and anemia may be implicated.
将父母的炎症性肠病（IBD）与儿童自闭症联系起来的证据尚无定论。我们进行了四项互补研究，以调查父母 IBD 与儿童自闭症之间的关联，并阐明其潜在病因。我们使用瑞典登记处进行了一项全国性基于人群的队列研究，发现父母 IBD 诊断与儿童自闭症之间存在关联。对雅芳纵向父母与子女研究的多基因风险评分分析表明，母亲患 IBD 的遗传易感性与儿童自闭症特征之间存在关联。两样本 Mendelian 随机分析为 IBD 遗传易感性，特别是溃疡性结肠炎，对自闭症的潜在因果效应提供了证据。连锁不平衡评分回归并未表明 IBD 和自闭症之间存在遗传相关性。这四种互补方法的证据相互印证，我们发现父母，特别是母亲的 IBD 与儿童自闭症之间存在潜在的因果关系。围产期免疫失调、微量营养素吸收不良和贫血可能与此有关。
