Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain; Carlos III Health Institute, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Barcelona; School of Medicine, University of Barcelona.
Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain; Carlos III Health Institute, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Barcelona.
J Am Acad Child Adolesc Psychiatry. 2018 Jan;57(1):41-47. doi: 10.1016/j.jaac.2017.10.016. Epub 2017 Nov 10.
Subclinical obsessive-compulsive (OC) symptoms are frequently observed in children and have been reported to predict a subsequent diagnosis of OC disorder (OCD). Therefore, identifying the putative neurobiological signatures of such risk is crucial, because it would allow for the characterization of the underpinnings of OCD without the interfering effects of chronicity, medication, or comorbidities, especially when interpreted within the context of OCD clinical heterogeneity and taking into account normal neurodevelopmental changes. The present study aimed to identify the brain volumetric features associated with subclinical OC symptoms and the potential modulatory effects of sex and age in a large sample of healthy children.
Two hundred fifty-five healthy children were assessed using the Obsessive-Compulsive Inventory-Child Version and underwent a brain structural magnetic resonance examination. The relation between total and symptom-specific scores and regional gray and white matter (GM and WM) volumes was evaluated. Participants were grouped according to sex and age (younger versus older) to assess the effect of these factors on symptom-brain morphometry associations.
Ordering symptoms were negatively related to GM volumes in the ventral caudate. Hoarding symptoms were positively associated with GM and WM volumes in the left inferior frontal gyrus, and obsessing symptoms correlated negatively with GM and WM volumes in the right temporal pole. Doubt-checking symptoms correlated positively with WM volumes in the right inferior fronto-occipital fasciculus and the corpus callosum. Sex and age modulated some of these associations.
Subclinical OC symptoms are associated with specific brain volumetric features, which could be considered potential neural signatures of increased risk for OCD.
亚临床强迫观念-强迫行为（OC）症状在儿童中经常被观察到，并且有研究报告称其可以预测随后的 OC 障碍（OCD）诊断。因此，确定这种风险的潜在神经生物学特征至关重要，因为这将允许在没有慢性、药物或合并症干扰的情况下，对 OCD 的潜在基础进行特征描述，尤其是在考虑到 OCD 临床异质性并考虑到正常神经发育变化的情况下。本研究旨在确定与亚临床 OC 症状相关的脑体积特征，以及在大量健康儿童中性别和年龄的潜在调节作用。
255 名健康儿童使用强迫观念-强迫行为量表儿童版进行评估，并进行了脑结构磁共振检查。评估了总症状和特定症状评分与区域灰质和白质（GM 和 WM）体积之间的关系。根据性别和年龄（年轻组与年长组）对参与者进行分组，以评估这些因素对症状-脑形态关联的影响。
序贯症状与腹侧尾状核的 GM 体积呈负相关。囤积症状与左侧额下回的 GM 和 WM 体积呈正相关，强迫症状与右侧颞极的 GM 和 WM 体积呈负相关。疑虑检查症状与右侧下额枕额束和胼胝体的 WM 体积呈正相关。性别和年龄调节了其中一些关联。
亚临床 OC 症状与特定的脑体积特征相关，这些特征可能被视为 OCD 风险增加的潜在神经生物学特征。
