Romer Adrienne L, Hubbard Nicholas A, Auerbach Randy P, Yendiki Anastasia, Ghosh Satrajit, Henin Aude, Hofmann Stefan G, Gabrieli John D E, Whitfield-Gabrieli Susan, Pizzagalli Diego A
Department of Psychology, Virginia Polytechnic Institute and State University, Blacksburg VA, USA.
Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA.
Clin Psychol Sci. 2025 Jul 27. doi: 10.1177/21677026251351850.
Brain structural alterations have been associated with internalizing symptoms concurrently. Less is known about whether these alterations relate to change in internalizing psychopathology during adolescence, a sensitive period for the effects of stress on neurodevelopment and internalizing symptoms. We examined whether cortical thickness (CT) was prospectively related to change in an internalizing factor in 203 adolescents (aged 14-17) with depression and/or anxiety diagnoses or no diagnosis from the Boston Adolescent Neuroimaging of Depression and Anxiety study. We conducted residualized change regression models to determine whether baseline CT was associated with one-year change in internalizing factor scores, and whether chronic stress exposure moderated these relations. Lower bilateral temporal pole and left insula CT were associated with one-year increases in internalizing factor scores and were moderated by chronic stress. These novel results identify specific cortical structure features that might contribute to worsening depression and anxiety, particularly in adolescents with high chronic stress.
脑结构改变一直与内化症状同时存在。对于这些改变是否与青少年期内化精神病理学的变化有关，人们所知较少，而青少年期是压力对神经发育和内化症状产生影响的敏感时期。我们在波士顿青少年抑郁与焦虑神经影像学研究中，对203名患有抑郁和/或焦虑诊断或无诊断的青少年（年龄14 - 17岁）进行了研究，以检验皮质厚度（CT）是否与内化因子的变化存在前瞻性关联。我们进行了残差变化回归模型，以确定基线CT是否与内化因子得分的一年变化相关，以及慢性应激暴露是否调节了这些关系。双侧颞极和左侧岛叶较低的CT与内化因子得分的一年增加相关，并受到慢性应激的调节。这些新结果确定了可能导致抑郁和焦虑恶化的特定皮质结构特征，尤其是在慢性应激较高的青少年中。
