锝-99m放射性标记的阴性脂质体在佐剂诱导性关节炎大鼠炎症爪子中的特异性蓄积：脂质体大小的影响
Specific accumulation of technetium-99m radiolabelled, negative liposomes in the inflamed paws of rats with adjuvant induced arthritis: effect of liposome size.
作者信息
Love W G, Amos N, Kellaway I W, Williams B D
机构信息
Pharmacy Department, University of Wales Institute of Science and Technology, Cardiff.
出版信息
Ann Rheum Dis. 1989 Feb;48(2):143-8. doi: 10.1136/ard.48.2.143.
Abstract
Technetium-99m labelled, negatively charged liposomes accumulate in the inflamed tissue of rats with adjuvant induced arthritis. Up to 10 times more liposome accumulation was seen in inflamed paws than in paws of control rats, and this represented 5.3% of the injected liposome dose. The accumulation of liposomes in inflamed tissue was directly related to the liposome size, the maximal accumulation occurring with liposomes less than 100 nm in diameter.
摘要
锝-99m标记的带负电荷脂质体在佐剂诱导性关节炎大鼠的炎症组织中聚集。在发炎的爪子中观察到的脂质体聚集量比对照大鼠爪子中的多10倍，这相当于注射脂质体剂量的5.3%。脂质体在炎症组织中的聚集与脂质体大小直接相关，直径小于100nm的脂质体聚集量最大。
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