a Department of Food Engineering, Faculty of Engineering , Munzur University , Tunceli , Turkey.
b Department of Biochemistry, Faculty of Veterinary Medicine , Ataturk University , Erzurum , Turkey.
Arch Physiol Biochem. 2018 Dec;124(5):448-457. doi: 10.1080/13813455.2017.1422766. Epub 2018 Jan 5.
Doxorubicin (DXR) is one of the most important chemotherapeutic agent. However, nephrotoxicity reduces its clinical utility in humans. The aim of the study was to investigate protective effects of curcumin (CMN) against DXR-induced nephrotoxicity. Rats were subjected to oral treatment of CMN (100 and 200 mg/kg body weight) for 7 days. Nephrotoxicity was induced by single intra peritoneal injection of DXR (40 mg/kg body weight) on the fifth day and then the experiment was terminated on the eighth day. Nephroprotective effects of CMN were associated with decrease in serum toxicity markers and increase in antioxidant enzyme activities. CMN was able to reduced the levels of inflammatory markers such as TNF-α, NF-κB, IL-1β, iNOS and COX-2 in the rats. It also reduced the expressions of apoptotic marker including caspase-3, and oxidative DNA damage marker including 8-OHdG. Collectively, these findings indicated that CMN protect against DXR-induced nephrotoxicity.
阿霉素（DXR）是最重要的化疗药物之一。然而，其肾毒性降低了它在人类中的临床应用。本研究旨在探讨姜黄素（CMN）对阿霉素诱导的肾毒性的保护作用。大鼠连续 7 天经口给予 CMN（100 和 200mg/kg 体重）。第 5 天单次腹腔注射阿霉素（40mg/kg 体重）诱导肾毒性，第 8 天实验结束。CMN 的肾保护作用与血清毒性标志物的降低和抗氧化酶活性的增加有关。CMN 能够降低 TNF-α、NF-κB、IL-1β、iNOS 和 COX-2 等炎症标志物在大鼠体内的水平。它还降低了凋亡标志物 caspase-3 和氧化 DNA 损伤标志物 8-OHdG 的表达。综上所述，这些发现表明 CMN 可预防阿霉素诱导的肾毒性。
