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Alantolactone protects against doxorubicin-induced nephrotoxicity by modulating Nrf2/HO-1, NF-κB, and Bax/Bcl-2 activity: molecular and in silico insights.

作者信息

Abuzinadah Mohammed F, Shaik Rasheed A, Ahmad Aftab, Islam Mohammed Nazrul, Eid Basma G

机构信息

Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.

Embryonic Stem Cells Research Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, 21859, Saudi Arabia.

出版信息

Mol Biol Rep. 2025 Jun 4;52(1):544. doi: 10.1007/s11033-025-10620-1.

DOI:10.1007/s11033-025-10620-1
PMID:40465003
Abstract
摘要

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本文引用的文献

1
Oxyresveratrol and/or Dapagliflozin Attenuate Doxorubicin-Induced Nephrotoxicity via Modulation of PPAR-γ/Nrf-2/HO-1, NF-κB/TNF-α/Keap-1, and Bcl-2/Caspase-3/ATG-5 signaling pathways in rats.氧化白藜芦醇和/或达格列净通过调节大鼠体内的PPAR-γ/Nrf-2/HO-1、NF-κB/TNF-α/Keap-1以及Bcl-2/Caspase-3/ATG-5信号通路减轻阿霉素诱导的肾毒性。
Naunyn Schmiedebergs Arch Pharmacol. 2025 May;398(5):5955-5967. doi: 10.1007/s00210-024-03608-4. Epub 2024 Dec 3.
2
Icariin inhibits cisplatin-induced ovarian toxicity via modulating NF-κB and PTEN/AKT/mTOR/AMPK axis.淫羊藿苷通过调节NF-κB和PTEN/AKT/mTOR/AMPK轴抑制顺铂诱导的卵巢毒性。
Naunyn Schmiedebergs Arch Pharmacol. 2025 Feb;398(2):1949-1959. doi: 10.1007/s00210-024-03395-y. Epub 2024 Aug 30.
3
Alantolactone improves cognitive impairment in rats with Porphyromonas gingivalis infection by inhibiting neuroinflammation, oxidative stress, and reducing Aβ levels.土木香内酯通过抑制神经炎症、氧化应激和降低β-淀粉样蛋白水平改善牙龈卟啉单胞菌感染大鼠的认知障碍。
Brain Res. 2024 Dec 15;1845:149203. doi: 10.1016/j.brainres.2024.149203. Epub 2024 Aug 28.
4
Phosphocreatine attenuates doxorubicin-induced nephrotoxicity through inhibition of apoptosis, and restore mitochondrial function via activation of Nrf2 and PGC-1α pathways.磷酸肌酸通过抑制细胞凋亡减轻阿霉素诱导的肾毒性，并通过激活 Nrf2 和 PGC-1α 通路来恢复线粒体功能。
Chem Biol Interact. 2024 Sep 1;400:111147. doi: 10.1016/j.cbi.2024.111147. Epub 2024 Jul 21.
5
Anethole alleviates Doxorubicin-induced cardiac and renal toxicities: Insights from network pharmacology and animal studies.茴芹素减轻阿霉素诱导的心脏和肾脏毒性：来自网络药理学和动物研究的见解。
Chem Biol Interact. 2024 Sep 25;401:111155. doi: 10.1016/j.cbi.2024.111155. Epub 2024 Jul 17.
6
Alantolactone attenuates high-fat diet-induced inflammation and oxidative stress in non-alcoholic fatty liver disease.土木香内酯可减轻非酒精性脂肪性肝病的高脂饮食诱导的炎症和氧化应激。
Nutr Diabetes. 2024 Jun 10;14(1):41. doi: 10.1038/s41387-024-00300-7.
7
Doxorubicin-induced cardiotoxicity and risk factors.多柔比星诱导的心脏毒性及危险因素。
Int J Cardiol Heart Vasc. 2023 Dec 27;50:101332. doi: 10.1016/j.ijcha.2023.101332. eCollection 2024 Feb.
8
Diosmin ameliorates renal fibrosis through inhibition of inflammation by regulating SIRT3-mediated NF-κB p65 nuclear translocation.地奥司明通过调节 SIRT3 介导的 NF-κB p65 核转位抑制炎症改善肾纤维化。
BMC Complement Med Ther. 2024 Jan 9;24(1):29. doi: 10.1186/s12906-023-04330-z.
9
Alantolactone Attenuates Renal Fibrosis via Inhibition of Transforming Growth Factor β/Smad3 Signaling Pathway.土木香内酯通过抑制转化生长因子β/Smad3信号通路减轻肾纤维化。
Diabetes Metab J. 2024 Jan;48(1):72-82. doi: 10.4093/dmj.2022.0231. Epub 2024 Jan 3.
10
Nrf2: a dark horse in doxorubicin-induced cardiotoxicity.Nrf2：阿霉素诱导心脏毒性中的一匹黑马。
Cell Death Discov. 2023 Jul 26;9(1):261. doi: 10.1038/s41420-023-01565-0.