Hobzova M, Sonka K, Pretl M, Vaclavik J, Kriegova E, Radvansky M, Zapletalova J, Plackova M, Kolek V
Department of Respiratory Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic.
Physiol Res. 2018 May 4;67(2):217-231. doi: 10.33549/physiolres.933570. Epub 2018 Jan 5.
Sleep apnoea (SA) is common in patients with hypertension. Nowadays, limited data on the prevalence of SA in nocturnal hypertension (NH) exist. Therefore, we studied the occurrence of SA in Czech patients and its association with 24-h ambulatory blood pressure monitoring (ABPM), breathing disturbances in sleep, anthropometric data, Mallampati score and Epworth sleepiness scale (ESS) using the Apnea Link device. Undiagnosed SA was found in 72.9 % patients (29.3 % mild, 26.6 % moderate, 17.0 % severe) of 188 patients with NH measured by ABPM. The median of the apnoea-hypopnoea index (AHI) was 12.0 (25th-75th percentile 5.0-23.8). Moderate/severe SA (AHI>/=15) was associated with BMI, waist circumference, mean night saturation (SpO(2)), t90, oxygen desaturation index (ODI), ESS (daytime BP only) (p</=0.032), but not ABPM parameters and Mallampati score (p>0.09). A likelihood of moderate/severe SA was enhanced by ODI>14.5 events/h (odds ratio=57.49, 95 % CI=22.79-145.01), t90>6.5 % (8.07, 4.09-15.92), mean night SpO(2)<93.5 % (3.55, 1.92-6.59), BMI>29.05 kg/m(2) (6.22, 3.10-12.49), circum waist>105.5 cm (3.73, 1.57-8.83), but not by any ABPM parameter. In conclusion, a high incidence of SA (72.9 %) was observed in Czech patients with NH. SA severity was associated with body characteristics and oxygenation parameters, but not with ABMP parameters and Mallampati score.
睡眠呼吸暂停（SA）在高血压患者中很常见。目前，关于夜间高血压（NH）患者中SA患病率的数据有限。因此，我们使用Apnea Link设备研究了捷克患者中SA的发生情况及其与24小时动态血压监测（ABPM）、睡眠呼吸紊乱、人体测量数据、马兰帕蒂评分和爱泼华嗜睡量表（ESS）的关系。通过ABPM测量的188例NH患者中，72.9%的患者发现了未诊断出的SA（轻度29.3%，中度26.6%，重度17.0%）。呼吸暂停低通气指数（AHI）的中位数为12.0（第25至75百分位数为5.0 - 23.8）。中度/重度SA（AHI≥15）与体重指数、腰围、夜间平均血氧饱和度（SpO₂）、t90、氧饱和度下降指数（ODI）、ESS（仅白天血压）相关（p≤0.032），但与ABPM参数和马兰帕蒂评分无关（p>0.09）。ODI>14.5次/小时（优势比=57.49，95%可信区间=22.79 - 145.01）、t90>6.5%（8.07，4.09 - 15.92）、夜间平均SpO₂<93.5%（3.55，1.92 - 6.59）、体重指数>29.05 kg/m²（6.22，3.10 - 12.49）、腰围>105.5 cm（3.73，1.57 - 8.83）会增加中度/重度SA的可能性，但与任何ABPM参数无关。总之，在捷克NH患者中观察到SA的高发病率（72.9%）。SA严重程度与身体特征和氧合参数相关，但与ABMP参数和马兰帕蒂评分无关。
